@article{fdi:010088184,
  title = {{D}aphnanes diterpenes from the latex of {H}ura crepitans {L}. and their {PKC} zeta;-dependent anti-proliferative activity on colorectal cancer cells},
  author = {{C}rossay, {E}. and {J}ullian, {V}al{\'e}rie and {T}rinel, {M}. and {S}agnat, {D}. and {H}amel, {D}. and {G}roppi, {E}. and {R}olland, {C}. and {S}tigliani, {J}. {L}. and {M}ejia, {K}. and {C}abanillas, {B}. {J}. and {A}lric, {L}. and {B}uscail, {E}. and {E}l {K}alamouni, {C}. and {M}avingui, {P}. and {D}eraison, {C}. and {R}acaud-{S}ultan, {C}. and {F}abre, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}ura crepitans {L}. ({E}uphorbiaceae) is a thorn-covered tree widespread in {S}outh {A}merica, {A}frica and {A}sia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diter-penes known as {P}rotein {K}inase {C} activators. {F}ractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. {H}uratoxin (6) and 4 & {PRIME};,5 & {PRIME};-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line {C}aco-2 and primary colorectal cancer cells cultured as colonoids. {T}he un-derlying mechanism of 4 and 6 was further investigated revealing the involvement of {PKC} & zeta;in the cytostatic activity.},
  keywords = {{E}uphorbiaceae ; {H}ura crepitans ; {D}aphnane diterpenes ; {C}olorectal cancer ; {C}aco-2 cells ; {P}rotein {K}inase {C}},
  booktitle = {},
  journal = {{B}ioorganic and {M}edicinal {C}hemistry},
  volume = {90},
  numero = {},
  pages = {117366 [17 ]},
  ISSN = {0968-0896},
  year = {2023},
  DOI = {10.1016/j.bmc.2023.117366},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088184},
}