@article{fdi:010086757,
  title = {{A}nti-{S}almonella activity of plant species in the {B}enin republic : {A}rtemisia afra and {D}etarium senegalense with promising in vitro and in vivo activities},
  author = {{A}moussa, {A}. {M}. {O}. and {L}agnika, {L}. and {J}ullian, {V}al{\'e}rie and {C}hassagne, {F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{N}on-typhoidal invasive {S}almonella ({NT}i{S}) diseases are one of the most important zoonoses in the world. {T}his study explored the antipathogenic potential of twenty-four plants used in {B}enin folk medicine against {NT}i{S} diseases. {T}he in vitro antibacterial and antibiofilm activities of ethanolic plant extracts were screened against clinical resistant isolates and {ATCC} reference strains of {S}almonella. {S}almonella enterica serovar {T}yphimuriuminfected rat model was used to examine the in vivo antibacterial potential of plant extracts. {O}f the 24 plants, 18 plants exhibited antibacterial activity against {S}almonella enterica strains with minimum inhibitory concentrations ({MIC}s) ranging from 0.156 to 1.25 mg/m{L}. {A}nacardium occidentale, {A}rtemisia afra, {D}etarium microcarpum, {D}etarium senegalense, and {L}eucaena leucocephala were the most active plant species. {E}xtracts from {A}. afra, {D}. microcarpum, and {D}. senegalense showed biofilm inhibition greater than 50% against {S}almonella clinical isolates. {I}n the rat model of infection, {A}. afra and {D}. senegalense extracts were found to have an effective dose of less than 100 mg/kg and to stop the salmonellosis after 10 days of treatment. {A}dditionally, these extracts did not produce any toxic effects in the treated animals. {T}hese results indicate clear evidence supporting the anti-{S}almonella activity of {A}. afra and {D}. senegalense. {F}urther studies are now needed to isolate bioactive compounds and to ensure the safety of these plant species.},
  keywords = {{Z}oonotic diseases ; {S}almonellosis ; {MIC} ; {A}ntibiofilm ; {M}edicinal plants ; {E}thnobotany ; {BENIN}},
  booktitle = {},
  journal = {{B}iomedicine and {P}harmacotherapy},
  volume = {158},
  numero = {},
  pages = {114119 [12 p.]},
  ISSN = {0753-3322},
  year = {2023},
  DOI = {10.1016/j.biopha.2022.114119},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086757},
}