@article{fdi:010086114,
  title = {{E}mergent and neglected equine filariosis in {E}gypt : species diversity and host immune response},
  author = {{A}bo-{A}ziza, {F}. {A}. {M}. and {H}endawy, {S}. {H}. {M}. and {A}bdullah, {H}ham and {E}l {N}amaky, {A}. and {L}aidoudi, {Y}. and {M}ediannikov, {O}leg},
  editor = {},
  language = {{ENG}},
  abstract = {{E}quine filariosis ({EF}) is a neglected vector-borne disease caused by nematode species belonging to the {O}nchocercidae and {S}etariidae families. {A}side from their zoonotic potential, some species are responsible for serious health problems in equids worldwide, leading to significant economic difficulties. {H}ere, we molecularly investigated equine blood samples (320 horses and 109 donkeys from {E}gypt) and four adult worms isolated from the peritoneal cavity of 5 out of the 94 slaughtered donkeys. {I}n addition, quantitative enzyme-linked immunoassays ({ELISA}s) targeting circulating cytokines were used to identify whether the immunological profile of the infected animals is a {T}h1 (i.e., {INF}-gamma as indicator) or {T}h2 (i.e., {IL}-5 and {IL}-10 as indicators) response type. {O}verall, 13.8% and 0.3% of the donkeys and horses, respectively, were scored as positive for filaroid {DNA}. {T}he 18{S} phylogeny revealed the occurrence of three different filaroid species, identified here as {M}ansonella ({T}etrapetalonema) sp., {S}etaria digitata and {D}irofilaria repens. {T}h1 ({INF}-gamma and {IL}-5) and {T}h2 ({IL}-10) immune response types were identified in equines infected with {S}. digitata and {M}ansonella ({T}.) sp., respectively. {T}hese results provide new data on the species diversity of {EF} in {E}gypt and extend knowledge of the downregulation of the protective immune response by the potentially zoonotic {M}ansonella ({T}) sp. {T}here is an urgent need to implement control measures to preserve equine health and limit the propagation of these vector-borne filaroids in {E}gypt.},
  keywords = {equids ; zoonotic filariosis ; cytokines ; phylogeny ; {M}ansonella sp ; {S}etaria digitata ; {D}irofilaria repens ; {EGYPTE}},
  booktitle = {},
  journal = {{P}athogens},
  volume = {11},
  numero = {9},
  pages = {979 [12 ]},
  year = {2022},
  DOI = {10.3390/pathogens11090979},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086114},
}