@article{fdi:010085893,
  title = {{H}ydra bioassay for the evaluation of chlordecone toxicity at environmental concentrations, alone or in complex mixtures with dechlorinated byproducts : experimental observations and modeling by experimental design},
  author = {{M}oreau, {X}. and {C}laeys-{B}runo, {M}. and {A}ndraud, {J}. {P}. and {M}acarie, {H}erv{\'e} and {M}artinez, {D}. {E}. and {R}obin, {M}. and {S}ergent, {M}. and {D}e {J}ong, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n chlordecone ({CLD})-contaminated soils of the {F}rench {W}est {I}ndies, if microbial remediation or a physicochemical remediation process, e.g., in situ chemical reduction, is implemented, concentrations of degradation byproducts, such as hydrochlordecones, are expected to increase in the ecosystems. {T}o study their impact in mixtures with {CLD}, bioassays were carried out. {T}hey consisted in evaluating the regenerative capacity of hydra polyps, from a clone whose phylogenetic analysis confirmed that it belonged to the species {H}ydra vulgaris {P}allas, 1766. {H}ydra gastric sections were exposed to {CLD} alone or {CLD} plus dechlorinated byproducts ({CLD}-{BP}) for 96 h to assess regeneration. {B}ased on chromatographic analysis, the {CLD}-{BP} mix was composed of the 5-monohydrochlordecone isomer ({CAS} nomenclature), four dihydrochlordecone isomers, and one trihydrochlordecone isomer representing 50%, 47%, and 3% of the total chromatographic area, respectively. {A} total of 18 mixtures of {CLD} and {CLD}-{BP} were tested. {S}ix environmental concentrations of {CLD} (2.10(-4) mu {M} to 4.10(-2) mu {M}) and a similar range of {CLD}-{BP} were used. {R}esults from exposures to {CLD} alone showed the following: (i) a significant decrease in the regenerative capacity of hydra, except at the lowest concentration (2.10(-4) mu {M}); (ii) a concentration-independent deleterious effect. {T}he regeneration scores obtained after the exposure to the addition of {CLD}-{BP} were not significantly different from those obtained after exposure to {CLD} alone. {U}sing an experimental design, a modeling of the regeneration scores of hydra exposed to mixtures is proposed. {I}nterpreted carefully, since they are limited to only one type of bioassay, the present results suggest that the situation in the aquatic environments should not become worse in terms of toxicity, if soil remediation programs resulting in the formation of hydrochlordecones are put in place.},
  keywords = {{H}ydra regeneration ; {E}cotoxicity ; {F}reshwaters ; {I}nsecticide ; {O}rganochlorine ; {M}odeling ; {E}xperimental design},
  booktitle = {},
  journal = {{E}nvironmental {S}cience and {P}ollution {R}esearch},
  volume = {29},
  numero = {},
  pages = {91017--91035},
  ISSN = {0944-1344},
  year = {2022},
  DOI = {10.1007/s11356-022-22050-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085893},
}