@article{fdi:010085366,
  title = {{C}omputer-aided analysis of {W}est {S}ub-{S}aharan {A}frica snakes venom towards the design of epitope-based poly-specific antivenoms},
  author = {{R}os-{L}ucas, {A}. and {B}igey, {P}. and {C}hippaux, {J}ean-{P}hilippe and {G}ascon, {J}. and {A}lonso-{P}adilla, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}nakebite envenomation is a neglected tropical disease that causes over 100,000 deaths each year. {T}he only effective treatment consists of antivenoms derived from animal sera, but these have been deemed with highly variable potency and are usually inaccessible and too costly for victims. {T}he production of antivenoms by venom-independent techniques, such as the immunization with multi-epitope constructs, could circumvent those drawbacks. {H}erein, we present a knowledge-based pipeline to prioritize potential epitopes of therapeutic relevance from toxins of medically important snakes in {W}est {S}ub-{S}aharan {A}frica. {I}t is mainly based on sequence conservation and protein structural features. {T}he ultimately selected 41 epitopes originate from 11 out of 16 snake species considered of highest medical importance in the region and 3 out of 10 of those considered as secondary medical importance. {E}chis ocellatus, responsible for the highest casualties in the area, would be covered by 12 different epitopes. {R}emarkably, this pipeline is versatile and customizable for the analysis of snake venom sequences from any other region of the world.},
  keywords = {antivenom ; snake bites ; snake venoms ; snakes ; {B}-cell epitopes ; {S}ub-{S}aharan {A}frica ; {AFRIQUE} {DE} {L}'{OUEST} ; {ZONE} {TROPICALE}},
  booktitle = {},
  journal = {{T}oxins},
  volume = {14},
  numero = {6},
  pages = {418 [16 ]},
  year = {2022},
  DOI = {10.3390/toxins14060418},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085366},
}