%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Compaore, C. F. A.
%A Kabore, J.
%A Ilboudo, H.
%A Thomas, L. F.
%A Falzon, L. C.
%A Bamba, M.
%A Sakande, H.
%A Kone, M.
%A Kaba, D.
%A Bougouma, C.
%A Adama, I.
%A Amathe, O.
%A Belem, A. M. G.
%A Fevre, E. M.
%A Buscher, P.
%A Lejon, Veerle
%A Jamonneau, Vincent
%T Monitoring the elimination of gambiense human African trypanosomiasis in the historical focus of Batie, South-West Burkina Faso
%D 2022
%L fdi:010085077
%G ENG
%J Parasite
%@ 1252-607X
%K Human African trypanosomiasis ; Trypanosoma brucei gambiense ; Elimination ; Diagnosis ; Rapid diagnostic test ; Specificity ; Dried blood ; spot ; Burkina Faso
%K BURKINA FASO
%K BATIE
%M ISI:000793426200001
%P 25 [10 ]
%R 10.1051/parasite/2022024
%U https://www.documentation.ird.fr/hor/fdi:010085077
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-06/010085077.pdf
%V 29
%W Horizon (IRD)
%X The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance of diagnostic tests and testing algorithms for detection of the re-emergence of Trypanosoma brucei gambiense HAT remains to be assessed. We carried out a door-to-door active medical survey for HAT in the historical focus of Batie, South-West Burkina Faso. Screening was done using three rapid diagnostic tests (RDTs). Two laboratory tests (ELISA/T. b. gambiense and immune trypanolysis) and parasitological examination were performed on RDT positives only. In total, 5883 participants were screened, among which 842 (14%) tested positive in at least one RDT. Blood from 519 RDT positives was examined microscopically but no trypanosomes were observed. The HAT Sero-K-Set test showed the lowest specificity of 89%, while the specificities of SD Bioline HAT and rHAT Sero-Strip were 92% and 99%, respectively. The specificity of ELISA/T. b. gambiense and trypanolysis was 99% (98-99%) and 100% (99-100%), respectively. Our results suggest that T. b. gambiense is no longer circulating in the study area and that zero transmission has probably been attained. While a least cost analysis is still required, our study showed that RDT preselection followed by trypanolysis may be a useful strategy for post-elimination surveillance in Burkina Faso.
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