@article{fdi:010084730,
  title = {{U}nderstanding dynamics of {P}lasmodium falciparum gametocytes production : insights from an age-structured model},
  author = {{D}jidjou-{D}emasse, {R}ams{\`e}s and {D}ucrot, {A}. and {M}ideo, {N}. and {T}exier, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}any models of within-host malaria infection dynamics have been formulated since the pioneering work of {A}nderson et al. in 1989. {B}iologically, the goal of these models is to understand what governs the severity of infections, the patterns of infectiousness, and the variation thereof across individual hosts. {M}athematically, these models are based on dynamical systems, with standard approaches ranging from {K}-compartments ordinary differential equations ({ODE}s) to delay differential equations ({DDE}s), to capture the relatively constant duration of replication and bursting once a parasite infects a host red blood cell. {U}sing malariatherapy data, which offers fine-scale resolution on the dynamics of infection across a number of individual hosts, we compare the fit and robustness of one of these standard approaches ({K} compartments {ODE}) with a partial differential equations ({PDE}s) model, which explicitly tracks the "age" of an infected cell. {W}hile both models perform quite similarly in terms of goodness-of-fit for suitably chosen {K}, the {K}-compartments {ODE} model particularly overestimates parasite densities early on in infections when the number of repeated compartments is not large enough. {F}inally, the {K}-compartments {ODE} model (for suitably chosen {K}) and the {PDE} model highlight a strong qualitative connection between the density of transmissible parasite stages (i.e., gametocytes) and the density of host-damaging (and asexually-replicating) parasite stages. {T}his finding provides a simple tool for predicting which hosts are most infectious to mosquitoes -vectors of {P}lasmodium parasites- which is a crucial component of global efforts to control and eliminate malaria.{C}rown {C}opyright (c) 2022 {P}ublished by {E}lsevier {L}td. {A}ll rights reserved.},
  keywords = {{W}ithin-host model ; {M}alaria ; {G}ametocytemia ; {P}arasitemia ; {I}nfectiousness},
  booktitle = {},
  journal = {{J}ournal of {T}heoretical {B}iology},
  volume = {539},
  numero = {},
  pages = {111056 [11 ]},
  ISSN = {0022-5193},
  year = {2022},
  DOI = {10.1016/j.jtbi.2022.111056},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084730},
}