@article{fdi:010083958,
  title = {{L}ifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite},
  author = {{S}eit{\'e}, {S}arah and {H}arrison, {M}. {C}. and {S}illam-{D}uss{\`e}s, {D}. and {L}upoli, {R}oland and {V}an {D}ooren, {T}. {J}. {M}. and {R}obert, {A}. and {P}oissonnier, {L}. {A}. and {L}emainque, {A}. and {R}enault, {D}. and {A}cket, {S}. and {A}ndrieu, {M}. and {V}iscarra, {J}. and {S}ul, {H}. {S}. and {D}e {B}eer, {Z}. {W}. and {B}ornberg-{B}auer, {E}. and {V}asseur-{C}ognet, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{K}ings and queens of eusocial termites can live for decades, while queens sustain a nearly maximal fertility. {T}o investigate the molecular mechanisms underlying their long lifespan, we carried out transcriptomics, lipidomics and metabolomics in {M}acrotermes natalensis on sterile short-lived workers, long-lived kings and five stages spanning twenty years of adult queen maturation. {R}eproductives share gene expression differences from workers in agreement with a reduction of several aging-related processes, involving upregulation of {DNA} damage repair and mitochondrial functions. {A}nti-oxidant gene expression is downregulated, while peroxidability of membranes in queens decreases. {A}gainst expectations, we observed an upregulated gene expression in fat bodies of reproductives of several components of the {IIS} pathway, including an insulin-like peptide, {I}lp9. {T}his pattern does not lead to deleterious fat storage in physogastric queens, while simple sugars dominate in their hemolymph and large amounts of resources are allocated towards oogenesis. {O}ur findings support the notion that all processes causing aging need to be addressed simultaneously in order to prevent it. {S}eite, {H}arrison, et al. investigate the mechanisms underlying long lifespan in queens and kings of the highly social termite {M}acrotermes natalensis. {U}sing transcriptomics, lipidomics and metabolomics, this study shows that several aging-related processes are reduced in the fat bodies of these reproductives and that an upregulated insulin-like peptide, {I}lp9, does not lead to deleterious fat storage in old queens, while simple sugars dominate in their hemolymph.},
  keywords = {},
  booktitle = {},
  journal = {{C}ommunications {B}iology},
  volume = {5},
  numero = {1},
  pages = {44 [16 ]},
  year = {2022},
  DOI = {10.1038/s42003-021-02974-6},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083958},
}