@article{fdi:010083827,
  title = {{A}rtemisinin-independent inhibitory activity of {A}rtemisia sp. infusions against different {P}lasmodium stages including relapse-causing hypnozoites},
  author = {{A}shraf, {K}. and {T}ajeri, {S}. and {A}rnold, {C}. {S}. and {A}manzougaghene, {N}. and {F}ranetich, {J}. {F}. and {V}antaux, {A}. and {S}oulard, {V}. and {B}ordessoulles, {M}. and {C}azals, {G}. and {B}ousema, {T}. and {V}an {G}emert, {G}. {J}. and {L}e {G}rand, {R}. and {D}ereuddre-{B}osquet, {N}. and {B}arale, {J}. {C}. and {W}itkowski, {B}. and {S}nounou, {G}. and {D}uval, {R}omain and {B}otte, {C}. {Y}. and {M}azier, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}rtemisinin-based combination therapies ({ACT}) are the frontline treatments against malaria worldwide. {R}ecently the use of traditional infusions from {A}rtemisia annua (from which arte-misinin is obtained) or {A}rtemisia afra (lacking artemisinin) has been controversially advocated. {S}uch unregulated plant-based remedies are strongly discouraged as they might constitute sub-optimal therapies and promote drug resistance. {H}ere, we conducted the first comparative study of the anti-malarial ef-fects of both plant infusions in vitro against the asexual erythrocytic stages of {P}lasmodium falciparum and the pre-erythrocytic (i.e., liver) stages of various {P}lasmodium species. {L}ow concentrations of either infusion accounted for significant inhibitory activities across every parasite species and stage studied. {W}e show that these antiplasmodial effects were essentially artemisinin-independent and were additionally monitored by observations of the parasite apicoplast and mitochondrion. {I}n particular, the infusions significantly incapacitated sporozoites, and for {P}lasmodium vivaz and {P}. cynomolgi, disrupted the hypnozoites. {T}his provides the first indication that compounds other than 8-aminoquinolines could be effective antimalarials against relapsing parasites. {T}hese observations advocate for further screening to uncover urgently needed novel antimalarial lead compounds.},
  keywords = {},
  booktitle = {},
  journal = {{L}ife {S}cience {A}lliance},
  volume = {5},
  numero = {3},
  pages = {e202101237 [12 ]},
  year = {2021},
  DOI = {10.26508/lsa.202101237},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083827},
}