@article{fdi:010083141,
  title = {{H}erpes infections in suspected cases of yellow fever in the {D}emocratic {R}epublic of the {C}ongo},
  author = {{M}akiala-{M}andanda, {S}. and {A}bbate, {J}. {L}. and {P}ukuta-{S}imbu, {E}. and {A}huka-{M}undeke, {S}. and {M}uyembe-{T}amfum, {J}. {J}. and {L}eroy, {E}ric and {B}ecquart, {P}ierre},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n the battle to quickly identify potential yellow fever arbovirus outbreaks in the {D}emocratic {R}epublic of the {C}ongo, active syndromic surveillance of acute febrile jaundice patients across the country is a powerful tool. {H}owever, patients who test negative for yellow fever virus infection are too often left without a diagnosis. {B}y retroactively screening samples for other potential viral infections, we can both try to find sources of patient disease and gain information on how commonly they may occur and co-occur. {S}everal human arboviruses have previously been identified, but there remain many other viral families that could be responsible for acute febrile jaundice. {H}ere, we assessed the prevalence of human herpes viruses ({HHV}s) in these acute febrile jaundice disease samples. {T}otal viral {DNA} was extracted from serum of 451 patients with acute febrile jaundice. {W}e used real-time quantitative {PCR} to test all specimens for cytomegalovirus ({CMV}), herpes simplex virus ({HSV}), human herpes virus type 6 ({HHV}-6) and varicella-zoster virus ({VZV}). {W}e found 21.3% had active {HHV} replication (13.1%, 2.4%, 6.2% and 2.4% were positive for {CMV}, {HSV}, {HHV}-6 and {VZV}, respectively), and that nearly half (45.8%) of these infections were characterized by co-infection either among {HHV}s or between {HHV}s and other viral infection, sometimes associated with acute febrile jaundice previously identified. {O}ur results show that the role of {HHV} primary infection or reactivation in contributing to acute febrile jaundice disease identified through the yellow fever surveillance program should be routinely considered in diagnosing these patients.},
  keywords = {herpes ; yellow fever ; {D}emocratic {R}epublic of the {C}ongo ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{M}edicina},
  volume = {57},
  numero = {9},
  pages = {871 [6 ]},
  ISSN = {1010-660{X}},
  year = {2021},
  DOI = {10.3390/medicina57090871},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083141},
}