%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ehounoud, B. C. H.
%A Koyo, C. S. B.
%A Bongue, L. D.
%A Cortaredona, Sébastien
%A Kakou, A. N.
%A Konan, D. B.
%A Patrick, Y. K.
%A Amanzougaghene, N.
%A N'Guessan, J. D.
%A Davoust, B.
%A Raoult, D.
%A Mediannikov, Oleg
%A Fenollar, F.
%T Assessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Cote d'Ivoire
%D 2021
%L fdi:010082787
%G ENG
%J Travel Medicine and Infectious Disease
%@ 1477-8939
%K Fever ; Bacteraemia ; Malaria ; Salmonella enterica ; Streptococcus pneumoniae ; Cote d'Ivoire
%K COTE D'IVOIRE
%M ISI:000693407400024
%P 102105 [9 ]
%R 10.1016/j.tmaid.2021.102105
%U https://www.documentation.ird.fr/hor/fdi:010082787
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2021-10/010082787.pdf
%V 43
%W Horizon (IRD)
%X Background: The aetiologies of fever are poorly understood in sub-Saharan Africa. We aimed to assess the burden of malaria and bacteria in Cote d'Ivoire. Methods: Blood samples from 438 febrile and 346 afebrile people were screened using molecular tools. Results: Plasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p < 0.001). Bacteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). Streptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p < 0.001). Non-typhoidal Salmonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p < 0.001). Salmonella enterica Typhi and S. enterica Paratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as Tropheryma whipplei (0.9%), Streptococcus pyogenes (0.7%), and Plasmodium ovale (4.6%). The prevalence in febrile and afebrile people was similar for Staphylococcus aureus (3.6-4.9%), Rickettsia felis (5.5-6.4%), Mansonella perstans (3.0-3.2%), and Plasmodium malariae (1.6-2.3%). Comorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving P. falciparum. All patients co-infected with P. falciparum and S. pneumoniae were febrile whereas 30% of those infected by P. falciparum alone were not (p = 0.02). Among febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy. Conclusion: Identification of etiologies of acute febrile diseases in sub-Saharan Africa proposes keys to successful treatment and prevention of infectious diseases. Vaccination campaigns may decrease the morbidity of monoand co-infections by preventable microorganisms.
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