@article{fdi:010082787,
  title = {{A}ssessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in {C}ote d'{I}voire},
  author = {{E}hounoud, {B}. {C}. {H}. and {K}oyo, {C}. {S}. {B}. and {B}ongue, {L}. {D}. and {C}ortaredona, {S}{\'e}bastien and {K}akou, {A}. {N}. and {K}onan, {D}. {B}. and {P}atrick, {Y}. {K}. and {A}manzougaghene, {N}. and {N}'{G}uessan, {J}. {D}. and {D}avoust, {B}. and {R}aoult, {D}. and {M}ediannikov, {O}leg and {F}enollar, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he aetiologies of fever are poorly understood in sub-{S}aharan {A}frica. {W}e aimed to assess the burden of malaria and bacteria in {C}ote d'{I}voire. {M}ethods: {B}lood samples from 438 febrile and 346 afebrile people were screened using molecular tools. {R}esults: {P}lasmodium falciparum was the most common microorganism associated with fever (46.8% in febrile, 23.4% in afebrile people; p < 0.001). {B}acteraemia was detected in 21.7% of febrile people and 12.7% of afebrile people (p = 0.001). {S}treptococcus pneumoniae was the main cause of bacteraemia (7.1% of febrile and 0.6% of afebrile individuals; p < 0.001). {N}on-typhoidal {S}almonella spp. was detected in 4.5% of febrile people and 1.2% of afebrile individuals (p < 0.001). {S}almonella enterica {T}yphi and {S}. enterica {P}aratyphi were only detected in febrile subjects (1.4% and 2.1%), as well as {T}ropheryma whipplei (0.9%), {S}treptococcus pyogenes (0.7%), and {P}lasmodium ovale (4.6%). {T}he prevalence in febrile and afebrile people was similar for {S}taphylococcus aureus (3.6-4.9%), {R}ickettsia felis (5.5-6.4%), {M}ansonella perstans (3.0-3.2%), and {P}lasmodium malariae (1.6-2.3%). {C}omorbidities were higher in febrile than in afebrile subjects (10.3% versus 5.5%; p = 0.01); 82% involving {P}. falciparum. {A}ll patients co-infected with {P}. falciparum and {S}. pneumoniae were febrile whereas 30% of those infected by {P}. falciparum alone were not (p = 0.02). {A}mong febrile participants, 30.4% with malaria and 54.7% with bacteraemia had received neither antimalarial nor antibiotic therapy. {C}onclusion: {I}dentification of etiologies of acute febrile diseases in sub-{S}aharan {A}frica proposes keys to successful treatment and prevention of infectious diseases. {V}accination campaigns may decrease the morbidity of monoand co-infections by preventable microorganisms.},
  keywords = {{F}ever ; {B}acteraemia ; {M}alaria ; {S}almonella enterica ; {S}treptococcus pneumoniae ; {C}ote d'{I}voire ; {COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{T}ravel {M}edicine and {I}nfectious {D}isease},
  volume = {43},
  numero = {},
  pages = {102105 [9 ]},
  ISSN = {1477-8939},
  year = {2021},
  DOI = {10.1016/j.tmaid.2021.102105},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082787},
}