@article{fdi:010082082,
  title = {{S}ynthesis, characterization, and antileishmanial activity of neutral gold({I}) complexes with {N}-heterocyclic carbene ligands bearing sulfur-containing side arms},
  author = {{F}touh, {S}. and {B}ourgeade-{D}elmas, {S}andra and {B}elkadi, {M}. and {D}eraeve, {C}. and {H}emmert, {C}. and {V}alentin, {A}. and {G}ornitzka, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}ith an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. {C}urrently available medical treatments involve side effects, including toxicity, nonspecific targeting, and resistance development. {T}hus, new antileishmanial chemical entities are of the utmost importance to fight against this disease. {W}e have shown in previous studies that gold({I}) complexes bearing {N}-heterocyclic carbene ({NHC}) ligands with nitrogen- or sulfur-containing side arms have interesting biological activities in the field of cancer, malaria and leishmaniasis. {T}he present study evaluates the in vitro antileishmanial effects on {L}. infantum axenic amastigotes and their cytotoxicity for the human {THP}1 cell line of a new family of six new imidazolium salts and their corresponding neutral ({NHC})({A}u{C}l)-{C}l-{I} complexes. {A}ll new compounds have been characterized by classical analytical methods, and five gold complexes have been analyzed by {X}-ray structure determinations. {W}e showed that one proligand has moderate activity ({IC}50 = 8.24 mu {M}) while four of the six gold complexes have {IC}50 values in the low or sub mu {M} range (0.15-1.3 mu {M}), including three with selectivity index ({SI}) values between 46 and 108. {T}hese results suggest remarkable leishmanicidal activity in vitro for three new neutral ({NHC}){A}u({I}){C}l complexes, making them candidates for further in vivo studies, which are under investigation.},
  keywords = {},
  booktitle = {},
  journal = {{O}rganometallics},
  volume = {40},
  numero = {10},
  pages = {1466--1473},
  ISSN = {0276-7333},
  year = {2021},
  DOI = {10.1021/acs.organomet.1c00113},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082082},
}