Publications des scientifiques de l'IRD

Lokmer A., Aflalo S., Amougou N., Lafosse S., Froment Alain, Ekwin Tabe F., Poyet M., Groussin M., Said-Mohamed R., Ségurel L. (2020). Response of the human gut and saliva microbiome to urbanization in Cameroon. Scientific Reports - Nature, 10 (1), 2856 [15 p.]. ISSN 2045-2322.

Titre du document
Response of the human gut and saliva microbiome to urbanization in Cameroon
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000560400000024
Auteurs
Lokmer A., Aflalo S., Amougou N., Lafosse S., Froment Alain, Ekwin Tabe F., Poyet M., Groussin M., Said-Mohamed R., Ségurel L.
Source
Scientific Reports - Nature, 2020, 10 (1), 2856 [15 p.] ISSN 2045-2322
Urban populations from highly industrialized countries are characterized by a lower gut bacterial diversity as well as by changes in composition compared to rural populations from less industrialized countries. To unveil the mechanisms and factors leading to this diversity loss, it is necessary to identify the factors associated with urbanization-induced shifts at a smaller geographical scale, especially in less industrialized countries. To do so, we investigated potential associations between a variety of dietary, medical, parasitological and socio-cultural factors and the gut and saliva microbiomes of 147 individuals from three populations along an urbanization gradient in Cameroon. We found that the presence of Entamoeba sp., a commensal gut protozoan, followed by stool consistency, were major determinants of the gut microbiome diversity and composition. Interestingly, urban individuals have retained most of their gut eukaryotic and bacterial diversity despite significant changes in diet compared to the rural areas, suggesting that the loss of bacterial microbiome diversity observed in industrialized areas is likely associated with medication. Finally, we observed a weak positive correlation between the gut and the saliva microbiome diversity and composition, even though the saliva microbiome is mainly shaped by habitat-related factors.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052] ; Nutrition, alimentation [054] ; Urbanisation et sociétés urbaines [102]
Localisation
Fonds IRD [F B010081735]
Identifiant IRD
fdi:010081735
Contact