Uncaria guianensis (Aubl.) J.F. Gmel. extracts reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma

2020

Article

Silva Zanetti L.da, Cagnoni Balestra A., Amorim J., Ramalho F.S., Souza Wanderley C.W.de, Mesquita Luiz J.P., Delprete Piero, Soares Pereira A.M., Carvalho Borges M.de, Carmona F.

Journal of Pharmacognosy and Phytotherapy, 2020, 12 (4), D1AB63A64968 [81-93] ISSN 2141-2502

Uncaria guianensis (Aubl.) J. F. Gmel. ("cat's claw", Rubiaceae) is a plant with potential to treat asthma because of its anti-inflammatory and antioxidant activities. The aim of this study was to evaluate the effects of two extracts of U. guianensisin an animal model of allergic asthma. Balb/c mice were sensitized twice with ovalbumin intraperitoneally one week apart, then challenged with intranasal ovalbumin for three days. Animals weretreated with aqueous or hydroethanolic extracts (100 mg/kg) for three days, simultaneously with ovalbumin challenges. Control mice received saline solution on the same days. In vivo bronchial hyper responsiveness, airway and lung inflammation, IgE levels, and total antioxidant capacitywere measured. Treatment with the hydroethanolic extract significantly reduced total cell and eosinophil counts in bronchoalveolar lavage, and in vivobronchial hyper responsiveness. Moreover, U. guianensis hydroethanolic extract significantly reduced interleukin 13 levels in lung homogenate. Total antioxidant capacity and IgE serum levels were not affected with the extract administration. Of note, treatment with the aqueous extract did not elicit significant effectson asthma-like characteristics. Only the hydroethanolic extractof U. guianensis reduced lung inflammation and bronchial hyper responsiveness in asthmatic mice

Santé : généralités [050] ; Sciences du monde végétal [076] ; Sciences du monde animal [080]

Fonds IRD [F B010081728]

fdi:010081728