@article{fdi:010080927,
  title = {{S}patiotemporal multiple insecticide resistance in {A}edes aegypti populations in {F}rench {G}uiana : need for alternative vector control},
  author = {{G}uidez, {A}. and {P}ocquet, {N}. and {R}estrepo, {J}. and {M}athieu, {L}. and {G}aborit, {P}. and {I}ssaly, {J}. and {C}arinci, {R}. and {C}handre, {F}abrice and {E}pelboin, {Y}. and {R}omain, {G}. and {D}usfour, {I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND} {A}edes aegypti is the sole vector of urban arboviruses in {F}rench {G}uiana. {O}vertime, the species has been responsible for the transmission of viruses during yellow fever, dengue, chikungunya and {Z}ika outbreaks. {D}ecades of vector control have produced resistant populations to deltamethrin, the sole molecule available to control adult mosquitoes in this {F}rench {T}erritory. {OBJECTIVES} {O}ur surveillance aimed to provide public health authorities with data on insecticide resistance in {A}e. aegypti populations and other species of interest in {F}rench {G}uiana. {M}onitoring resistance to the insecticide used for vector control and to other molecule is a key component to develop an insecticide resistance management plan. {METHODS} {I}n 2009, we started to monitor resistance phenotypes to deltamethrin and target-site mechanisms in {A}e. aegypti populations across the territory using the {WHO} impregnated paper test and allelic discrimination assay. {FINDINGS} {E}ight years surveillance revealed well-installed resistance and the dramatic increase of alleles on the sodium voltage-gated gene, known to confer resistance to pyrethroids ({PY}). {I}n addition, we observed that populations were resistant to malathion (organophosphorous, {OP}) and alpha-cypermethrin ({PY}). {S}ome resistance was also detected to molecules from the carhamate family. {F}inally, those populations somehow recovered susceptibility against fenitrothion ({OP}). {I}n addition, other species distributed in urban areas revealed to be also resistant to pyrethroids. {CONCLUSION} {T}he resistance level can jeopardize the efficiency of chemical adult control in absence of other alternatives and conducts to strongly rely on larval control measures to reduce mosquito burden. {V}ector control strategies need to evolve to maintain or regain efficacy during epidemics.},
  keywords = {{A}edes aegypti ; insecticide resistance ; {F}rench {G}uiana ; spatioternporal ; distribution ; {GUYANE} {FRANCAISE}},
  booktitle = {},
  journal = {{M}emorias {D}o {I}nstituto {O}swaldo {C}ruz},
  volume = {115},
  numero = {},
  pages = {e200313 [9 p.]},
  ISSN = {0074-0276},
  year = {2020},
  DOI = {10.1590/0074-02760200313},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080927},
}