@article{fdi:010080793,
  title = {{M}ice immunization with {T}rypanosoma brucei gambiense translationally controlled tumor protein modulates immunoglobulin and cytokine production, as well as parasitaemia and mice survival after challenge with the parasite},
  author = {{B}ossard, {G}. and {R}odrigues, {V}. and {T}our, {E}. and {G}eiger, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{F}ighting trypanosomiasis with an anti-trypanosome vaccine is ineffective, the parasite being protected by a {V}ariable {S}urface {G}lycoprotein ({VSG}) whose structure is modified at each peak of parasitaemia, which allows it to escape the host's immune defenses. {H}owever, the host immunization against an essential factor for the survival of the parasite or the expression of its pathogenicity could achieve the same objective. {H}ere we present the results of mouse immunization against the {T}ranslationally {C}ontrolled {T}umor {P}rotein ({TCTP}), a protein present in the {T}rypanosoma brucei gambiense ({T}bg) secretome, the parasite responsible for human trypanosomiasis. {M}ice immunization was followed by infection with {T}bg parasites. {T}he production of {I}g{G}, {I}g{G}1 and {I}g{G}2a begun after the second {TCTP} injection and was dose-dependant, the maximum level of anti-{TCTP} antibodies remained stable up to 4 days post-infection and then decreased. {R}egarding cytokines ({IL}-2, 4, 6, 10, {INF}?, {TNF}?), the most striking result was their total suppression after immunization with the highest {TCTP} dose. {C}ompared to the control group, the immunized mice displayed a reduced first peak of parasitaemia, a 100% increase in the time to onset of the second peak, and an increased time of mice survival. {T}he effect of immunization was only transient but demonstrated the likely important role that {TCTP} plays in host-parasite interactions and that some key parasite proteins could reduce infection impact},
  keywords = {},
  booktitle = {},
  journal = {{I}nfection, {G}enetics and {E}volution},
  volume = {87},
  numero = {},
  pages = {104636 [13 ]},
  ISSN = {1567-1348},
  year = {2021},
  DOI = {10.1016/j.meegid.2020.104636},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080793},
}