%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Bouyer, G.
%A Barbieri, D.
%A Dupuy, F.
%A Marteau, A.
%A Sissoko, A.
%A N'Dri, M. E.
%A Neveu, G.
%A Bedault, L.
%A Khodabux, N.
%A Roman, D.
%A Houze, S.
%A Siciliano, G.
%A Alano, P.
%A Martins, R. M.
%A Lopez-Rubio, J. J.
%A Clain, J.
%A Duval, Romain
%A Egee, S.
%A Lavazec, C.
%T Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability
%D 2020
%L fdi:010080465
%G ENG
%J Communications Biology
%M ISI:000598828900001
%N 1
%P 726 [10 ]
%R 10.1038/s42003-020-01454-7
%U https://www.documentation.ird.fr/hor/fdi:010080465
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers21-01/010080465.pdf
%V 3
%W Horizon (IRD)
%X Bouyer et al. report that the new permeation pathways (NPP), responsible of modulating erythrocyte permeability to diverse solutes and considered only to be in pathogenic asexual stages of P. falciparum, are also active in erythrocytes infected with immature gametocytes and this activity declines with gametocyte maturation. NPPs are regulated by the cAMP signalling cascade, and the decrease in cAMP levels in mature stages slows NPP activity. To ensure the transport of nutrients necessary for their survival, Plasmodium falciparum parasites increase erythrocyte permeability to diverse solutes. These new permeation pathways (NPPs) have been extensively characterized in the pathogenic asexual parasite stages, however the existence of NPPs has never been investigated in gametocytes, the sexual stages responsible for transmission to mosquitoes. Here, we show that NPPs are still active in erythrocytes infected with immature gametocytes and that this activity declines along gametocyte maturation. Our results indicate that NPPs are regulated by cyclic AMP (cAMP) signaling cascade, and that the decrease in cAMP levels in mature stages results in a slowdown of NPP activity. We also show that NPPs facilitate the uptake of artemisinin derivatives and that phosphodiesterase (PDE) inhibitors can reactivate NPPs and increase drug uptake in mature gametocytes. These processes are predicted to play a key role in P. falciparum gametocyte biology and susceptibility to antimalarials.
%$ 052 ; 020