@article{fdi:010080465,
  title = {{P}lasmodium falciparum sexual parasites regulate infected erythrocyte permeability},
  author = {{B}ouyer, {G}. and {B}arbieri, {D}. and {D}upuy, {F}. and {M}arteau, {A}. and {S}issoko, {A}. and {N}'{D}ri, {M}. {E}. and {N}eveu, {G}. and {B}edault, {L}. and {K}hodabux, {N}. and {R}oman, {D}. and {H}ouze, {S}. and {S}iciliano, {G}. and {A}lano, {P}. and {M}artins, {R}. {M}. and {L}opez-{R}ubio, {J}. {J}. and {C}lain, {J}. and {D}uval, {R}omain and {E}gee, {S}. and {L}avazec, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ouyer et al. report that the new permeation pathways ({NPP}), responsible of modulating erythrocyte permeability to diverse solutes and considered only to be in pathogenic asexual stages of {P}. falciparum, are also active in erythrocytes infected with immature gametocytes and this activity declines with gametocyte maturation. {NPP}s are regulated by the c{AMP} signalling cascade, and the decrease in c{AMP} levels in mature stages slows {NPP} activity. {T}o ensure the transport of nutrients necessary for their survival, {P}lasmodium falciparum parasites increase erythrocyte permeability to diverse solutes. {T}hese new permeation pathways ({NPP}s) have been extensively characterized in the pathogenic asexual parasite stages, however the existence of {NPP}s has never been investigated in gametocytes, the sexual stages responsible for transmission to mosquitoes. {H}ere, we show that {NPP}s are still active in erythrocytes infected with immature gametocytes and that this activity declines along gametocyte maturation. {O}ur results indicate that {NPP}s are regulated by cyclic {AMP} (c{AMP}) signaling cascade, and that the decrease in c{AMP} levels in mature stages results in a slowdown of {NPP} activity. {W}e also show that {NPP}s facilitate the uptake of artemisinin derivatives and that phosphodiesterase ({PDE}) inhibitors can reactivate {NPP}s and increase drug uptake in mature gametocytes. {T}hese processes are predicted to play a key role in {P}. falciparum gametocyte biology and susceptibility to antimalarials.},
  keywords = {},
  booktitle = {},
  journal = {{C}ommunications {B}iology},
  volume = {3},
  numero = {1},
  pages = {726 [10 ]},
  year = {2020},
  DOI = {10.1038/s42003-020-01454-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080465},
}