@article{fdi:010080448,
  title = {{I}midazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology},
  author = {{M}olinaro, {A}. and {B}el {L}assen, {P}y and {H}enricsson, {M}. and {W}u, {H}. and {A}driouch, {S}. and {B}elda, {E}. and {C}hakaroun, {R}. and {N}ielsen, {T}. and {B}ergh, {P}. {O}. and {R}ouault, {C}. and {A}ndre, {S}. and {M}arquet, {F}. and {A}ndreelli, {F}. and {S}alem, {J}. {E}. and {A}ssmann, {K}. and {B}astard, {J}. {P}. and {F}orslund, {S}. and {L}e {C}hatelier, {E}. and {F}alony, {G}. and {P}ons, {N}. and {P}rifti, {E}di and {Q}uinquis, {B}. and {R}oume, {H}. and {V}ieira-{S}ilva, {S}. and {H}ansen, {T}. {H}. and {P}edersen, {H}. {K}. and {L}ewinter, {C}. and {S}onderskov, {N}. {B}. and {K}ober, {L}. and {V}estergaard, {H}. and {H}ansen, {T}. and {Z}ucker, {J}ean-{D}aniel and {G}alan, {P}. and {D}umas, {M}. {E}. and {R}aes, {J}. and {O}ppert, {J}. {M}. and {L}etunic, {I}. and {N}ielsen, {J}. and {B}ork, {P}. and {E}hrlich, {S}. {D}. and {S}tumvoll, {M}. and {P}edersen, {O}. and {A}ron-{W}isneswky, {J}. and {C}lement, {K}. and {B}ackhed, {F}. and {M}eta{C}ardis {C}onsortium},
  editor = {},
  language = {{ENG}},
  abstract = {{M}icrobiota-host-diet interactions contribute to the development of metabolic diseases. {I}midazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. {H}ere, we show that subjects with prediabetes and diabetes in the {M}eta{C}ardis cohort from three {E}uropean countries have elevated serum imidazole propionate levels. {F}urthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and {B}acteroides 2 enterotype, which have previously been associated with obesity. {T}he {B}acteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. {S}ince patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. {T}hus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism. {G}ut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate ({I}m{P}) is produced by type 2 diabetes ({T}2{D}) associated microbiome. {H}ere the authors report that circulating {I}m{P} levels are increased in subjects with prediabetes or {T}2{D} in three {E}uropean populations, and this increase associates with altered gut microbiota rather than dietary histidine.},
  keywords = {{FRANCE} ; {ALLEMAGNE} ; {DANEMARK}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {11},
  numero = {1},
  pages = {5881 [10 ]},
  ISSN = {2041-1723},
  year = {2020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010080448},
}