Messi L. M., Note O. P., Mbing J. N., Lavedan P., Vedrenne M., Ouedraogo N., Carraz Maëlle, Bourgeade-Delmas Sandra, Pegnyemb D. E., Haddad Mohamed. (2020). Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines [+ Corrigendum, vol. 175, 2024, 105934]. Fitoterapia, 146, 104669 [9 p.] + [Corrigendum, 1 p.]. ISSN 0367-326X.
Titre du document
Triterpenoid saponins from Calliandra calothyrsus Meisn. and their antiproliferative activity against two digestive carcinoma human cell lines [+ Corrigendum, vol. 175, 2024, 105934]
Année de publication
2020
Auteurs
Messi L. M., Note O. P., Mbing J. N., Lavedan P., Vedrenne M., Ouedraogo N., Carraz Maëlle, Bourgeade-Delmas Sandra, Pegnyemb D. E., Haddad Mohamed
Source
Fitoterapia, 2020,
146, 104669 [9 p.] + [Corrigendum, 1 p.] ISSN 0367-326X
The chemical investigation of the flowers and twigs of Calliandra calothyrsus (Fabaceae) led to the isolation of three new oleanane-type triterpenoid saponins, named calothyrsusosides A-C (1-3). Their structures were established by direct interpretation of their spectral data, mainly HRESIMS, 1D NMR and 2D NMR (H-1, H-1 NMR DOSY, C-13 NMR, COSY, HSQC, HMBC, HSQC-TOCSY and NOESY) and by comparison with literature data. Compounds 1 and 2 were tested for their antiproliferative activity against two digestive carcinoma human cell lines: Hep3B (hepatocellular carcinoma) and Caco-2 (epithelial colorectal adenocarcinoma). Both compounds exhibited an antiproliferative activity against the Hep3B cell line, with IC50 values of 6.0 and 6.5 mu M, respectively, while no effect was detected against the epithelial colorectal adenocarcinoma Caco-2 (CC50 > 25 mu M).
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010079929]
Identifiant IRD
fdi:010079929
