Trinel M., Le Lamer A. C., Jullian Valérie, Jacquemin D., Graton J., Cristofoli V., Crossay E., Yassine M., Rolland C., Vergnolle N., Mejia K., Cabanillas B. J., Racaud-Sultan C., Fabre N. (2020). Daphnanes diterpenes from the latex of Hura crepitans L. and activity against human colorectal cancer cells Caco-2. Bioorganic Chemistry, 103, 104132 [13 p.]. ISSN 0045-2068.
Titre du document
Daphnanes diterpenes from the latex of Hura crepitans L. and activity against human colorectal cancer cells Caco-2
Année de publication
2020
Auteurs
Trinel M., Le Lamer A. C., Jullian Valérie, Jacquemin D., Graton J., Cristofoli V., Crossay E., Yassine M., Rolland C., Vergnolle N., Mejia K., Cabanillas B. J., Racaud-Sultan C., Fabre N.
Source
Bioorganic Chemistry, 2020,
103, 104132 [13 p.] ISSN 0045-2068
Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1-3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Sciences du monde végétal [076]
Localisation
Fonds IRD [F B010079802]
Identifiant IRD
fdi:010079802
