@article{fdi:010079713,
  title = {{D}eterminants of {P}lasmodium falciparum multiplicity of infection and genetic diversity in {B}urkina {F}aso},
  author = {{S}ondo, {P}. and {D}erra, {K}. and {R}ouamba, {T}. and {D}iallo, {S}. {N}. and {T}aconet, {P}aul and {K}azienga, {A}. and {I}lboudo, {H}. and {T}ahita, {M}. {C}. and {V}alea, {I}. and {S}orgho, {H}. and {L}ef{\`e}vre, {T}hierry and {T}into, {H}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}nvestigating malaria transmission dynamics is essential to inform policy decision making. {W}hether multiplicity of infection ({MOI}) dynamic from individual infections could be a reliable malaria metric in high transmission settings with marked variation in seasons of malaria transmission has been poorly assessed. {T}his study aimed at investigating factors driving {P}lasmodium falciparum {MOI} and genetic diversity in a hyperendemic area of {B}urkina {F}aso. {M}ethods: {B}lood samples collected from a pharmacovigilance trial were used for polymerase chain reaction genotyping of the merozoite surface proteins 1 and 2. {MOI} was defined as the number of distinct parasite genotypes co-existing within a particular infection. {M}onthly rainfall data were obtained from satellite data of the {G}lobal {P}recipitation {M}easurement {D}atabase while monthly malaria incidence aggregated data were extracted from {D}istrict {H}ealth {I}nformation {S}oftware 2 medical data of the {C}enter-{W}est health regional direction. {R}esults: {I}n the study area, infected people harboured an average of 2.732 (+/- 0.056) different parasite genotypes. {A} significant correlation between the monthly {MOI} and the monthly malaria incidence was observed, suggesting that {MOI} could be a good predictor of transmission intensity. {A} strong effect of season on {MOI} was observed, with infected patients harbouring higher number of parasite genotypes during the rainy season as compared to the dry season. {T}here was a negative relationship between {MOI} and host age. {I}n addition, {MOI} decreased with increasing parasite densities, suggesting that there was a within-host competition among co-infecting genetically distinct{P}. falciparumvariants. {E}ach allelic family of themsp1andmsp2genes was present all year round with no significant monthly fluctuation. {C}onclusions: {I}n high malaria endemic settings with marked variation in seasons of malaria transmission, {MOI} represents an appropriate malaria metric which provides useful information about the longitudinal changes in malaria transmission in a given area. {B}esides transmission season, patient age and parasite density are important factors to consider for better understanding of variations in {MOI}. {A}ll allelic families ofmsp1andmsp2genes were found in both dry and rainy season. {T}he approach offers the opportunity of translating genotyping data into relevant epidemiological information for malaria control.},
  keywords = {{M}alaria ; {P}lasmodium falciparum ; {M}ultiplicity of infection ; msp1 ; msp2 ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {13},
  numero = {1},
  pages = {427 [12 p.]},
  ISSN = {1756-3305},
  year = {2020},
  DOI = {10.1186/s13071-020-04302-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079713},
}