%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Nararak, J.
%A Di Giorgio, C.
%A Sukkanon, C.
%A Mahiou-Leddet, V.
%A Ollivier, E.
%A Manguin, Sylvie
%A Chareonviriyaphap, T.
%T Excito-repellency and biological safety of beta-caryophyllene oxide against Aedes albopictus and Anopheles dirus (Diptera : Culicidae)
%D 2020
%L fdi:010079579
%G ENG
%J Acta Tropica
%@ 0001-706X
%K Excito-repellency test system ; beta-Caryophyllene oxide ; Phototoxic ; Genotoxic ; Mosquitoes
%M ISI:000563534800015
%P 105556 [10 ]
%R 10.1016/j.actatropica.2020.105556
%U https://www.documentation.ird.fr/hor/fdi:010079579
%> https://www.documentation.ird.fr/intranet/publi/2020/09/010079579.pdf
%V 210
%W Horizon (IRD)
%X The activity of beta-caryophyllene oxide as either a contact or noncontact repellent was evaluated against two laboratory strains (Aedes albopictus and Anopheles dirus) using an excito-repellency test system. N, N-Diethyl-3methylbenzamide (DEET) was used as a standard reference baseline for comparative purposes. beta-Caryophyllene oxide and DEET were tested at concentrations of 0.1, 0.25, 0.5 and 1.0% (v/v). In addition, the phototoxic and genotoxic effects of beta-caryophyllene oxide were investigated on Balb/c 3T3 mouse fibroblasts (3T3-L1) and Chinese hamster ovary cell line (CHO-K1). The results demonstrated that the higher concentrations of test compounds (0.5 and 1.0%) produced greater behavioral responses. Aedes albopictus was more sensitive to beta beta-caryophyllene oxide than An. dirus. Moderate avoidance response rates (25-56% escape) of Ae. albopictus at 0.5% and 1.0% beta-caryophyllene oxide were observed in contact and noncontact trials compared with low response rates from An. dirus (26-31% escape). DEET at <= 1% displayed lower irritancy and repellency (1-38%) than beta-caryophyllene oxide when tested against the two mosquito species. Knockdown responses (37%) were only observed in An. dirus exposed to 1% 0-caryophyllene oxide in the contact trial. beta-Caryophyllene oxide did not show any phototoxic potential (PIF= 0.38) nor was there any significant genotoxic response as indicated by no increase in micro-nucleated cells with or without metabolic activation. beta-Caryophyllene oxide could be considered as a safe repellent, effective against mosquitoes.
%$ 052 ; 020