@article{fdi:010079579,
  title = {{E}xcito-repellency and biological safety of beta-caryophyllene oxide against {A}edes albopictus and {A}nopheles dirus ({D}iptera : {C}ulicidae)},
  author = {{N}ararak, {J}. and {D}i {G}iorgio, {C}. and {S}ukkanon, {C}. and {M}ahiou-{L}eddet, {V}. and {O}llivier, {E}. and {M}anguin, {S}ylvie and {C}hareonviriyaphap, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he activity of beta-caryophyllene oxide as either a contact or noncontact repellent was evaluated against two laboratory strains ({A}edes albopictus and {A}nopheles dirus) using an excito-repellency test system. {N}, {N}-{D}iethyl-3methylbenzamide ({DEET}) was used as a standard reference baseline for comparative purposes. beta-{C}aryophyllene oxide and {DEET} were tested at concentrations of 0.1, 0.25, 0.5 and 1.0% (v/v). {I}n addition, the phototoxic and genotoxic effects of beta-caryophyllene oxide were investigated on {B}alb/c 3{T}3 mouse fibroblasts (3{T}3-{L}1) and {C}hinese hamster ovary cell line ({CHO}-{K}1). {T}he results demonstrated that the higher concentrations of test compounds (0.5 and 1.0%) produced greater behavioral responses. {A}edes albopictus was more sensitive to beta beta-caryophyllene oxide than {A}n. dirus. {M}oderate avoidance response rates (25-56% escape) of {A}e. albopictus at 0.5% and 1.0% beta-caryophyllene oxide were observed in contact and noncontact trials compared with low response rates from {A}n. dirus (26-31% escape). {DEET} at <= 1% displayed lower irritancy and repellency (1-38%) than beta-caryophyllene oxide when tested against the two mosquito species. {K}nockdown responses (37%) were only observed in {A}n. dirus exposed to 1% 0-caryophyllene oxide in the contact trial. beta-{C}aryophyllene oxide did not show any phototoxic potential ({PIF}= 0.38) nor was there any significant genotoxic response as indicated by no increase in micro-nucleated cells with or without metabolic activation. beta-{C}aryophyllene oxide could be considered as a safe repellent, effective against mosquitoes.},
  keywords = {{E}xcito-repellency test system ; beta-{C}aryophyllene oxide ; {P}hototoxic ; {G}enotoxic ; {M}osquitoes},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {210},
  numero = {},
  pages = {105556 [10 p.]},
  ISSN = {0001-706{X}},
  year = {2020},
  DOI = {10.1016/j.actatropica.2020.105556},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079579},
}