@article{fdi:010079486,
  title = {{C}linical and epidemiologic characteristics associated with dengue during and outside the 2016 outbreak identified in health facility-based surveillance in {O}uagadougou, {B}urkina {F}aso},
  author = {{L}im, {J}. {K}. and {S}eydou, {Y}. and {C}arabali, {M}. and {B}arro, {A}. and {D}ahourou, {D}. {L}. and {L}ee, {K}. {S}. and {N}ikiema, {T}. and {N}amkung, {S}. and {L}ee, {J}. {S}. and {S}hin, {M}. {Y}. and {B}onnet, {E}mmanuel and {K}agone, {T}. and {K}aba, {L}. and {E}dwards, {T}. and {S}ome, {P}. {A}. and {Y}ang, {J}. {S}. and {A}lexander, {N}. and {Y}oon, {I}. {K}. and {R}idde, {V}al{\'e}ry},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}n {A}frica, the magnitude of dengue virus ({DENV}) transmission is largely unknown. {I}n {B}urkina {F}aso, several outbreaks have been reported and data are often based on findings from outbreak investigations. {M}ethods {T}o better understand dengue epidemiology and clinical characteristics in {B}urkina {F}aso, a fever surveillance study was conducted among patients aged 1-55 years, who presented with non-malarial febrile illness at five primary healthcare facilities in {O}uagadougou, {B}urkina {F}aso from {D}ecember 2014 to {F}ebruary 2017, encompassing a 3-month dengue outbreak in {S}eptember-{N}ovember 2016. {A}cute and convalescent blood samples were collected within an interval of 10-21 days between visits. {A}cute samples were tested with dengue rapid diagnostic tests ({RDT}) and a selected subset with {RT}-{PCR}, and all acute/convalescent samples with {I}g{M}/{I}g{G} {ELISA}. {R}esults {A}mong 2929 non-malarial febrile patients, 740 (25%) were dengue-positive based on {RTPCR} and/or {I}g{M}/{I}g{G} {ELISA}; 428 out of 777 patients (55%) and 312 out of 2152 (14%) were dengue-positive during outbreak and non-outbreak periods, respectively. {T}here were 11% (316/2929) and 4% (129/2929) patients showing positive for {NS}1 and {I}g{M}, on the {RDT}, respectively. {DENV} 2 predominated during the outbreak, whereas {DENV} 3 predominated before the outbreak. {O}nly 25% of dengue-positive cases were clinically diagnosed with suspected dengue. {T}he odds of requiring observation for <= 3 days (versus routine outpatient care) were 11 times higher among dengue-positive cases than non-dengue cases. {I}n adjusted analyses, dengue-positivity was associated with rash and retro-orbital pain ({OR} = 2.6 and 7.4, respectively) during the outbreak and with rash and nausea/vomiting ({OR} = 1.5 and 1.4, respectively) during the non-outbreak period. {C}onclusion {D}engue virus is an important pathogen in {B}urkina {F}aso, accounting for a substantial proportion of non-malarial fevers both during and outside outbreak, but is only infrequently suspected by clinicians. {A}dditional longitudinal data would help to further define characteristics of dengue for improved case detection and surveillance.},
  keywords = {{BURKINA} {FASO} ; {OUAGADOUGOU}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {13},
  numero = {12},
  pages = {art. e0007882 [21 ]},
  ISSN = {1935-2735},
  year = {2019},
  DOI = {10.1371/journal.pntd.0007882},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079486},
}