@article{fdi:010079269,
  title = {{A} distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects [plus {S}upplementary data]},
  author = {{M}utch, {D}.{M}. and {P}ers, {T}.{H}. and {T}emanni,  {M}.{R}. and {P}elloux, {V}. and {M}arquez-{Q}uiñones, {A}. and {H}olst, {C}. and {M}artinez,  {J}.{A}.  and {B}abalis, {D}. and {V}an {B}aak, {M}.{A}. and {H}andjieva-{D}arlenska, {T}. and {W}alker, {C}.{G}. and {A}strup, {A}. and {S}aris, {W}.{H}.{M}. and {L}angin, {D}. and {V}iguerie, {N}. and {Z}ucker, {J}ean-{D}aniel and {C}l{\'e}ment, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground : {W}eight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes ; however, successful maintenance of weight loss continues to pose a challenge. {O}bjective : {T}he present study was designed to assess whether changes in subcutaneous adipose tissue (sc{AT}) gene expression during a low-calorie diet ({LCD}) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. {D}esign : {F}orty white women followed a dietary protocol consisting of an 8-wk {LCD} phase followed by a 6-mo weight-maintenance phase. {P}articipants were classified as weight maintainers ({WM}s; 0-10% weight regain) and weight regainers ({WR}s; 50-100% weight regain) by considering changes in body weight during the 2 phases. {A}nthropometric measurements, bioclinical variables, and sc{AT} gene expression were studied in all individuals before and after the {LCD}. {E}nergy intake was estimated by using 3-d dietary records. {R}esults: {N}o differences in body weight and fasting insulin were observed between {WM}s and {WR}s at baseline or after the {LCD} period. {T}he {LCD} resulted in significant decreases in body weight and in several plasma variables in both groups. {WM}s experienced a significant reduction in insulin secretion in response to an oral-glucose-tolerance test after the {LCD}; in contrast, no changes in insulin secretion were observed in {WR}s after the {LCD}. {A}n {ANOVA} of sc{AT} gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the {LCD} in {WM} and {WR} subjects. {C}onclusion: {T}his study suggests that {LCD}-induced changes in insulin secretion and sc{AT} gene expression may have the potential to predict successful short-term weight maintenance. {T}his trial was registered at clinicaltrials.gov as {NCT}00390637.},
  keywords = {},
  booktitle = {},
  journal = {{T}he {A}merican {J}ournal of {C}linical {N}utrition},
  volume = {94},
  numero = {6},
  pages = {1399--1409 [+ 4 p.]},
  ISSN = {0002-9165},
  year = {2011},
  DOI = {10.3945/ajcn.110.006858},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079269},
}