@article{fdi:010079247,
  title = {{MERS} coronaviruses from camels in {A}frica exhibit region-dependent genetic diversity [r{\'e}sum{\'e}]},
  author = {{C}hu, {D}.{K}.{W}. and {H}ui, {K}.{P}.{Y}. and {P}errera, {R}.{A}.{P}.{M}. and {M}iguel, {E}ve and {O}ladipo, {J}.{O}. and {T}raor{\'e}, {A}. and {F}assi-{F}ihri, {O}. and {C}han, {M}.{C}.{W}. and {Z}hou, {Z}. and {S}o, {R}.{T}.{Y}. and {C}hevalier, {V}. and {P}eiris, {J}.{S}.{M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}iddle {E}ast respiratory syndrome coronavirus ({MERS}-{C}o{V}) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the only proven source of this zoonotic infection. {A}lthough {MERS}-{C}o{V} infection is ubiquitous in dromedaries across {A}frica and the {A}rabian {P}eninsula, the continuous appearance of zoonotic {MERS} cases in humans is confined to the {A}rabian {P}eninsula. {MERS}-{C}o{V} from {A}frica has hitherto been poorly studied. {H}ere, we report the genetic and phenotypic characterization of {MERS}-{C}o{V} from dromedaries in {A}frican countries. {P}hylogenetically, viruses from dromedaries in {A}frica formed a monophyletic clade, which we have provisionally designated as virus clade {C}. {M}olecular dating analyses of {MERSC}o{V}, including clade {C} viruses, suggests that the ancestral {MERSC}o{V} in dromedaries could have spread to the two continents within a short timeframe. {C}amel {MERS}-{C}o{V}s fromwest and north {A}frican countries form a subclade ({C}1) that shares genetic signatures of a major deletion in the accessory gene {ORF}4b. {C}ompared with human and camel {MERS}-{C}o{V} from {S}audi {A}rabia, virus isolates from {B}urkina {F}aso ({BF}785) and {N}igeria ({N}ig1657) had lower virus replication competence in {C}alu-3 cells and in ex vivo cultures of human bronchus and lung, and {BF}785 replicated to lower titer in lungs of human {DPP}4-transduced mice. {H}owever, it is still inconclusive whether {ORF}4b deletions may lead to the reduced replication competence of {BF}785 and {N}ig1657. {G}enetic and phenotypic differences in {W}est {A}frican viruses may be relevant to the zoonotic potential of {MERS}-{C}o{V}.},
  keywords = {{MOYEN} {ORIENT} ; {AFRIQUE} {DE} {L}'{OUEST} ; {MAROC} ; {BURKINA} {FASO} ; {NIGERIA} ; {ETHIOPIE}},
  booktitle = {},
  journal = {{V}irus {E}volution},
  volume = {5},
  numero = {suppl.1},
  pages = {{S}16},
  ISSN = {2057-1577},
  year = {2019},
  DOI = {10.1093/ve/vez002.051},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079247},
}