%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Makinson, A.
%A Dubois, J.
%A Eymard-Duvernay, Sabrina
%A Leclercq, P.
%A Zaegel-Faucher, O.
%A Bernard, L.
%A Vassallo, M.
%A Barbuat, C.
%A Gény, C.
%A Thouvenot, E.
%A Costagliola, D.
%A Ozguler, A.
%A Zins, M.
%A Simony, M.
%A Reynes, J.
%A Berr, C.
%T Increased prevalence of neurocognitive impairment in aging people living with human immunodeficiency virus : the anrs ep58 hand 55-70 study
%D 2020
%L fdi:010079229
%G ENG
%J Clinical Infectious Diseases
%@ 1058-4838
%K FRANCE
%M ISI:000551516200034
%N 12
%P 2641-2648
%R 10.1093/cid/ciz670
%U https://www.documentation.ird.fr/hor/fdi:010079229
%> https://www.documentation.ird.fr/intranet/publi/depot/2020-06-26/010079229.pdf
%V 70
%W Horizon (IRD)
%X Background.There are limited data on the comparative prevalence of neurocognitive impairment (NCI) in aging people living with human immunodeficiency virus (PLHIV) and people not living with HIV. Methods.This was a cross-sectional study of PLHIV randomly matched by age (±4 years), gender, and education with 5 HIV-uninfected individuals from the CONSTANCES cohort. PLHIV were fluent in French and sequentially included during routine outpatient visits if aged 55-70 years, with HIV viral load <50 copies/mL, and lymphocyte T-CD4 level >-200 cells/uL in the past 24 and 12 months, respectively. The primary outcome was NCI as defined by the Frascati criteria. Multivariate normative comparison (MNC) and -1.5 standard deviations in >-2 neurocognitive domains were secondary outcomes of NCI. Results.Two hundred PLHIV were matched with 1000 controls. Median age was 62 years, and 85% were men. In PLHIV, the median T-CD4 lymphocyte level was 650 cells/uL, and median nadir T-CD4 lymphocyte level was 176 cells/uL. NCI was found in 71 (35.5%) PLHIV and in 242 (24.2%) controls (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.25, 2.41). After adjusting for confounders, HIV remained significantly associated with NCI (OR, 1.50; 95% CI, 1.04, 2.16). Adjusted results were similar with NCI defined by MNC (ORMNC, 2.95; 95% CI, 1.13, 3.50) or -1.5 SD (OR-1.5, 2.24; 95% CI, 1.39, 3.62). Conclusions.In this matched study of aging individuals, HIV was significantly associated with an increased risk of NCI after adjusting for major confounders. Results were confirmed with more stringent NCI classifications.
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