Publications des scientifiques de l'IRD

Di Ciaccio M., Sagaon Teyssier Luis, Mimi M., Suzan-Monti M., Protiere C., Castro D. R., Meyer L., Tremblay C., Chidiac C., Capitant C., Preau M., Molina J. M., Spire B., ANRS IPERGAY Study Group. (2020). Changes in sexual behaviors in men who have sex with men : a comparison between the double-blind and open-label extension phases of the ANRS-IPERGAY trial. AIDS and Behavior, 24 (11), 3093-3106. ISSN 1090-7165.

Titre du document
Changes in sexual behaviors in men who have sex with men : a comparison between the double-blind and open-label extension phases of the ANRS-IPERGAY trial
Année de publication
2020
Type de document
Article référencé dans le Web of Science WOS:000527516000001
Auteurs
Di Ciaccio M., Sagaon Teyssier Luis, Mimi M., Suzan-Monti M., Protiere C., Castro D. R., Meyer L., Tremblay C., Chidiac C., Capitant C., Preau M., Molina J. M., Spire B., ANRS IPERGAY Study Group
Source
AIDS and Behavior, 2020, 24 (11), 3093-3106 ISSN 1090-7165
Pre-Exposure Prophylaxis (PrEP) is changing the landscape of HIV prevention, and may bring changes in sexual behaviors. The double-blind phase (DBP) and open-label extension (OLE) study of the ANRS-IPERGAY trial allowed us to assess changes in sexual behavior of men who have sex with men (MSM) taking sexual activity-based (i.e., on-demand) PrEP. Generalized Estimating Equation (GEE) models found a significant decrease in the number of sexual partners (Coefficient [CI95%], p value; - 0.37[- 0.70 to - 0.04], p = 0.03) between the DBP and OLE as well as in the number of sexual relations (- 0.25 [- 0.49 to 0.00], 0.04). GEE estimates also showed that respondents' most recent sexual relation was less likely to have been with an unknown casual partner during the OLE than during the DBP (Odds Ratio [CI95%], p value: 0.75[0.62-0.92], 0.005). Furthermore, they showed an increase in the proportion of condomless anal sex in the OLE (1.32[1.04-1.67], 0.02), a decrease in the proportion of 'suboptimal PrEP adherence' over time (0.75[0.58-0.97], p = 0.03), a decrease in PrEP only use (0.73[0.55-0.96], 0.03) and in both PrEP and condom use over time (0.70[0.51-0.95], 0.02) and finally, a decrease in alcohol consumption between the DBP and OLE (0.74[0.61-0.90], 0.002). We observed both protective and risky behaviors in terms of HIV and STI risk after on-demand PrEP uptake in the OLE phase. Our findings are consistent with results from previous PrEP trials.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052] ; Santé : aspects socioculturels, économiques et politiques [056]
Description Géographique
FRANCE ; CANADA
Localisation
Fonds IRD [F B010078987]
Identifiant IRD
fdi:010078987
Contact