@article{fdi:010078608,
  title = {{C}omparative genome analysis of the yellow fever mosquito {A}edes aegypti with {D}rosophila melanogaster and the malaria vector mosquito {A}nopheles gambiae},
  author = {{S}everson, {D}.{W}. and {D}e {B}ruyn, {B}. and {L}ovin, {D}.{D}. and {B}rown, {S}.{E}. and {K}nudson, {D}.{L}. and {M}orlais, {I}sabelle},
  editor = {},
  language = {{ENG}},
  abstract = {{A}n in silico comparative genomics approach was used to identify putative orthologs to genetically mapped genes from the mosquito, {A}edes aegypti, in the {D}rosophila melanogaster and {A}nopheles gambiae genome databases. {C}omparative chromosome positions of 73 {D}. melanogaster orthologs indicated significant deviations from a random distribution across each of the five {A}. aegypti chromosomal regions, suggesting that some ancestral chromosome elements have been conserved. {H}owever, the two genomes also reflect extensive reshuffling within and between chromosomal regions. {C}omparative chromosome positions of {A}. gambiae orthologs indicate unequivocally that {A}. aegypti chromosome regions share extensive homology to the five {A}. gambiae chromosome arms. {W}hole-arm or near-whole-arm homology was contradicted with only two genes among the 75 {A}. aegypti genes for which orthologs to {A}. gambiae were identified. {T}he two genomes contain large conserved chromosome segments that generally correspond to break/fusion events and a reciprocal translocation with extensive paracentric inversions evident within. {O}nly very tightly linked genes are likely to retain conserved linear orders within chromosome segments. {T}he {D}. melanogaster and {A}. gambiae genome databases therefore offer limited potential for comparative positional gene determinations among even closely related dipterans, indicating the necessity for additional genome sequencing projects with other dipteran species.},
  keywords = {{FIEVRE} {JAUNE} ; {PALUDISME} ; {VECTEUR} ; {MOUSTIQUE} ; {GENETIQUE} {DE} {POPULATION} ; {LIAISON} {GENETIQUE} ; {BIOLOGIE} {MOLECULAIRE} ; {ETUDE} {COMPARATIVE} ; {GENOMIQUE}},
  booktitle = {},
  journal = {{J}ournal of {H}eredity},
  volume = {95},
  numero = {3},
  pages = {103--113},
  ISSN = {0022-1503},
  year = {2004},
  DOI = {10.1093/jhered/esh023},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078608},
}