@article{fdi:010078470,
  title = {{D}esign, synthesis and efficacy of hybrid triclosan-gold based molecules on artemisinin-resistant {P}lasmodium falciparum and {L}eishmania infantum parasites},
  author = {{O}uji, {M}. and {B}ourgeade-{D}elmas, {S}andra and {A}lvaro {F}ernández, {A}. and {A}ugereau, {J}.{M}. and {V}alentin, {A}. and {H}ennert, {C}. and {G}ornitzka, {H}. and {B}enoit-{V}ical, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he emergence of resistant parasites, {P}lasmodium and {L}eishmania, responsible of malaria and leishmaniasis diseases, to the currently available drugs, remains one of the major threats to public health. {T}herefore, there is an urgent need to develop new molecules. {S}everal hybrid molecules combining triclosan and gold ({I}) complexes have been synthesized and evaluated, in vitro, for their activities on {P}. falciparum and {L}. infantum parasites. {T}he obtained results showed a good activity of the compounds. {H}owever, the cytotoxicity assays suggest a structure modulation to improve the selectivity. {T}he synthesized molecules were also tested in a context of {P}lasmodium falciparum artemisinin-resistance and the results showed no cross-resistance induced between one gold({I}) complex and artemisinin. {T}his highlights that these compounds appear as a strong basis for further pharmacomodulation work to propose molecules targeting resistant parasites.},
  keywords = {},
  booktitle = {},
  journal = {{C}hemistry{S}elect},
  volume = {5},
  numero = {2},
  pages = {619--625},
  ISSN = {2365-6549},
  year = {2020},
  DOI = {10.1002/slct.201904345},
  URL = {https://www.documentation.ird.fr/hor/fdi:010078470},
}