Catalano S., Leger E., Fall C. B., Borlase A., Diop S. D., Berger D., Webster B. L., Faye B., Diouf N. D., Rollinson D., Sene M., Ba Khalilou, Webster J. P. (2020). Multihost transmission of Schistosoma mansoni in Senegal, 2015-2018. Emerging Infectious Diseases, 26 (6), p. 1234-1242. ISSN 1080-6040.
Titre du document
Multihost transmission of Schistosoma mansoni in Senegal, 2015-2018
Année de publication
2020
Auteurs
Catalano S., Leger E., Fall C. B., Borlase A., Diop S. D., Berger D., Webster B. L., Faye B., Diouf N. D., Rollinson D., Sene M., Ba Khalilou, Webster J. P.
Source
Emerging Infectious Diseases, 2020,
26 (6), p. 1234-1242 ISSN 1080-6040
In West Africa, Schistosoma spp. are capable of infecting multiple definitive hosts, a lifecycle feature that may complicate schistosomiasis control. We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. On a local scale, diagnosis of S. mansoni infection ranged 3.8%-44.8% in school-aged children, 1.7%-52.6% in Mastomys huberti mice, and 1.8%-7.1% in Biomphalaria pfeifferi snails. Our phylogenetic framework confirmed the presence of multiple S. mansoni lineages that could infect both humans and rodents; divergence times of these lineages varied (0.13-0.02 million years ago). We propose that extensive movement of persons across West Africa might have contributed to the establishment of these various multihost S. mansoni clades. High S. mansoni prevalence in rodents at transmission sites frequented by humans further highlights the implications that alternative hosts could have on future public health interventions.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
Description Géographique
SENEGAL
Localisation
Fonds IRD [F B010078222]
Identifiant IRD
fdi:010078222
