%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Carboué, Q.
%A Maresca, M.
%A Herbette, G.
%A Roussos, Sevastianos
%A Hamrouni, R.
%A Bombarda, I.
%T Naphtho-gamma-pyrones produced by Aspergillus tubingensis G131: new source of natural nontoxic antioxidants
%D 2020
%L fdi:010077960
%G ENG
%J Biomolecules
%K naphtho-gamma-pyrones ; radical scavenging activity ; hydrogen peroxide ; mediated cell death assay ; solid state fermentation ; Aspergillus tubingensis
%M ISI:000514863200016
%N 1
%P art. 29 [15 ]
%R 10.3390/biom10010029
%U https://www.documentation.ird.fr/hor/fdi:010077960
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-04/010077960.pdf
%V 10
%W Horizon (IRD)
%X Seven naphtho-gamma-pyrones (N gamma Ps), including asperpyrone E, aurasperone A, dianhydroaurasperone C, fonsecin, fonsecinone A, fonsecin B, and ustilaginoidin A, were isolated from Aspergillus tubingensis G131, a non-toxigenic strain. The radical scavenging activity of these N gamma Ps was evaluated using ABTS assay. The Trolox equivalent antioxidant capacity on the seven isolated N gamma Ps ranged from 2.4 to 14.6 mu mol L-1. The toxicity and ability of the N gamma Ps to prevent H2O2-mediated cell death were evaluated using normal/not cancerous cells (CHO cells). This cell-based assay showed that N gamma Ps: (1) Are not toxic or weakly toxic towards cells and (2) are able to protect cells from oxidant injuries with an IC50 on H2O2-mediated cell death ranging from 2.25 to 1800 mu mol mL(-1). Our data show that A. tubingensis G131 strain is able to produce various N gamma Ps possessing strong antioxidant activities and low toxicities, making this strain a good candidate for antioxidant applications in food and cosmetic industries.
%$ 084 ; 020