@article{fdi:010077960,
  title = {{N}aphtho-gamma-pyrones produced by {A}spergillus tubingensis {G}131: new source of natural nontoxic antioxidants},
  author = {{C}arbou{\'e}, {Q}. and {M}aresca, {M}. and {H}erbette, {G}. and {R}oussos, {S}evastianos and {H}amrouni, {R}. and {B}ombarda, {I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}even naphtho-gamma-pyrones ({N} gamma {P}s), including asperpyrone {E}, aurasperone {A}, dianhydroaurasperone {C}, fonsecin, fonsecinone {A}, fonsecin {B}, and ustilaginoidin {A}, were isolated from {A}spergillus tubingensis {G}131, a non-toxigenic strain. {T}he radical scavenging activity of these {N} gamma {P}s was evaluated using {ABTS} assay. {T}he {T}rolox equivalent antioxidant capacity on the seven isolated {N} gamma {P}s ranged from 2.4 to 14.6 mu mol {L}-1. {T}he toxicity and ability of the {N} gamma {P}s to prevent {H}2{O}2-mediated cell death were evaluated using normal/not cancerous cells ({CHO} cells). {T}his cell-based assay showed that {N} gamma {P}s: (1) {A}re not toxic or weakly toxic towards cells and (2) are able to protect cells from oxidant injuries with an {IC}50 on {H}2{O}2-mediated cell death ranging from 2.25 to 1800 mu mol m{L}(-1). {O}ur data show that {A}. tubingensis {G}131 strain is able to produce various {N} gamma {P}s possessing strong antioxidant activities and low toxicities, making this strain a good candidate for antioxidant applications in food and cosmetic industries.},
  keywords = {naphtho-gamma-pyrones ; radical scavenging activity ; hydrogen peroxide ; mediated cell death assay ; solid state fermentation ; {A}spergillus tubingensis},
  booktitle = {},
  journal = {{B}iomolecules},
  volume = {10},
  numero = {1},
  pages = {art. 29 [15 ]},
  year = {2020},
  DOI = {10.3390/biom10010029},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077960},
}