Fonseca A. M., Gonzalez R., Bardaji A., Jairoce C., Ruperez M., Jimenez A., Quinto L., Cistero P., Vala A., Sacoor C., Gupta H., Hegewisch-Taylor J., Brew J., Tuikue Ndam Nicaise, Kariuki S., Lopez M., Dobano C., Chitnis C. E., Ouma P., Ramharter M., Abdulla S., Aponte J. J., Massougbodji A., Briand Valérie, Mombo-Ngoma G., Desai M., Cot Michel, Nhacolo A., Sevene E., Macete E., Menendez C., Mayor A. (2019). VAR2CSA serology to detect Plasmodium falciparum transmission patterns in pregnancy. Emerging Infectious Diseases, 25 (10), p. 1851-1860. ISSN 1080-6040.
Titre du document
VAR2CSA serology to detect Plasmodium falciparum transmission patterns in pregnancy
Année de publication
2019
Auteurs
Fonseca A. M., Gonzalez R., Bardaji A., Jairoce C., Ruperez M., Jimenez A., Quinto L., Cistero P., Vala A., Sacoor C., Gupta H., Hegewisch-Taylor J., Brew J., Tuikue Ndam Nicaise, Kariuki S., Lopez M., Dobano C., Chitnis C. E., Ouma P., Ramharter M., Abdulla S., Aponte J. J., Massougbodji A., Briand Valérie, Mombo-Ngoma G., Desai M., Cot Michel, Nhacolo A., Sevene E., Macete E., Menendez C., Mayor A.
Source
Emerging Infectious Diseases, 2019,
25 (10), p. 1851-1860 ISSN 1080-6040
Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
MOZAMBIQUE ; BENIN ; GABON ; KENYA ; TANZANIE
Localisation
Fonds IRD [F B010077099]
Identifiant IRD
fdi:010077099
