Horizon / Plein textes La base de ressources documentaires de l'IRD

IRD

 

Publications des scientifiques de l'IRD

Dao M. C., Belda E., Prifti E., Everard A., Kayser B. D., Bouillot J. L., Chevallier J. M., Pons N., Le Chatelier E., Ehrlich S. D., Doré J., Aron-Wisnewsky J., Zucker Jean-Daniel, Cani P. D., Clément K. (2019). Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement. American Journal of Physiology : Endocrinology and Metabolism, 317 (3), E446-E459. ISSN 0193-1849

Accès réservé (Intranet IRD) Demander le PDF

Lien direct chez l'éditeur doi:10.1152/ajpendo.00140.2019

Titre
Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement
Année de publication2019
Type de documentArticle référencé dans le Web of Science WOS:000486307700004
AuteursDao M. C., Belda E., Prifti E., Everard A., Kayser B. D., Bouillot J. L., Chevallier J. M., Pons N., Le Chatelier E., Ehrlich S. D., Doré J., Aron-Wisnewsky J., Zucker Jean-Daniel, Cani P. D., Clément K.
SourceAmerican Journal of Physiology : Endocrinology and Metabolism, 2019, 317 (3), p. E446-E459. ISSN 0193-1849
RésuméThe gut bacterial species Akkermansia muciniphila is associated with a healthier clinical profile. The purpose of this study was to determine the association between A. muciniphila and glucose homeostasis in patients undergoing bariatric surgery (BS): gastric banding (GB) or Roux-en-Y gastric bypass (RYGB). This nonrandomized prospective study included 65 women with severe obesity. Longitudinal analysis included subjects for whom A. muciniphila data were available at follow-up [1, 3, and 12 mo; GB (n = 10) or RYGB (n = 11)]. Glucose homeostasis markers were measured under fasting conditions (glucose. insulin, and HbAlc) or during an oral glucose tolerance test. Fecal microbiota was analyzed using shotgun metagenomics, and A. muciniphila relative abundance was assessed with 16S rRNA quantitative PCR. A. muciniphila relative abundance was significantly lower in severe obesity [mean body mass index. 45.7 kg/m(2) (SD 5.4)] than in moderate obesity [33.2 kg/m(2) (SD 3.8)] but not associated with glucose homeostasis markers. A significant increase in A. muciniphila relative abundance after RYGB was not correlated with metabolic improvement. Baseline A. muciniphila abundance was correlated with bacterial gene richness and was highest in the high-richness Ruminococcaceae enterotype. A. muciniphila increased in relative abundance after BS in patients with low baseline A. muciniphila abundance, especially those with a Bacteroides type 2 enterotype classification. Although decreased in severe obesity, relative abundance of A. muciniphila was not associated with glucose homeostasis before or after BS. A certain level of A. muciniphila abundance might be required to observe a beneficial link to health. The severity of obesity and gut dysbiosis may partly explain the discrepancy with previous findings in less obese populations.
Plan de classementNutrition, alimentation [054] ; Santé : généralités [050] ; Biotechnologies [084]
LocalisationFonds IRD [F B010077040]
Identifiant IRDfdi:010077040
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010077040

Export des données

Disponibilité des documents

Télechargment fichier PDF téléchargeable

Lien sur le Web lien chez l'éditeur

Accès réservé en accès réservé

HAL en libre accès sur HAL


Accès aux documents originaux :

Le FDI est labellisé CollEx

Accès direct

Bureau du chercheur

Site de la documentation

Espace intranet IST (accès réservé)

Suivi des publications IRD (accès réservé)

Mentions légales

Services Horizon

Poser une question

Consulter l'aide en ligne

Déposer une publication (accès réservé)

S'abonner au flux RSS

Voir les tableaux chronologiques et thématiques

Centres de documentation

Bondy

Montpellier (centre IRD)

Montpellier (MSE)

Cayenne

Nouméa

Papeete

Abidjan

Dakar

Niamey

Ouagadougou

Tunis

La Paz

Quito