@article{fdi:010077037,
  title = {{B}urden and impacts of chronic hepatitis {B} infection in rural {S}enegal : study protocol of a cross-sectional survey in the area of {N}iakhar ({A}m{BASS} {ANRS} 12356)},
  author = {{C}oste, {M}. and {S}eze, {M}. and {D}iallo, {A}. and {C}arrieri, {M}. {P}. and {M}arcellin, {F}. and {B}oyer, {S}. and {B}erenger, {C}. and {B}ousmah, {M}. {A}. and {C}arrieri, {P}. and {C}oste, {M}. and {D}jaogol, {T}. and {M}aradan, {G}. and {T}reibich, {C}. and {B}a, {E}. and {D}ieye, {F}. and {D}iouf, {A}. and {F}aye, {E}. {B}. and {N}diaye, {A}. and {P}erieres, {L}. and {S}okhna, {C}heikh and {K}ane, {C}. {T}. and {L}o, {G}. and {N}diaye, {A}. {J}. {S}. and {N}diour, {S}. and {H}alfon, {P}. and {M}ohamed, {S}. and {R}ouveau, {N}. and {C}ortes, {M}. {C}. {C}. and {L}aborde-{B}alen, {G}. and {A}udibert, {M}. and {F}all, {F}. and {G}ueye, {I}. and {L}acombe, {K}. and {S}eydi, {M}. and {S}himakawa, {Y}. and {T}uaillon, {E}. and {V}ray, {M}. and {ANRS} 12356 {A}m{BASS} {S}tudy {G}roup},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {T}hough {S}enegal has one of the highest estimated prevalence rates of chronic hepatitis {B} virus ({HBV}) infection worldwide, epidemiological data in the general population are lacking and consequences of the infection remain undocumented. {T}he {ANRS}-12356 {A}m{BASS} study aims at evaluating the health and socioeconomic burden of chronic {HBV} infection at the individual, household and population level. {I}ts specific objectives are (1) to document the epidemiology of chronic {HBV} infection, including prevalence and risk factors; (2) to assess the acceptability of home-based testing and first clinic visit; (3) to investigate the repercussions of chronic {HBV} infection on living conditions; and (4) to estimate the public health impact of chronic {HBV} infection at the population level and the feasibility of a decentralised model of {HBV} test and treat. {M}ethods and analysis {T}his multidisciplinary cross-sectional survey includes a twofold data collection: (1) home-based screening using dried blood spot ({DBS}) sampling and collection of sociodemographic, economic and behavioural data, and (2) additional clinical and biological data collection in chronic {HBV} carriers at the first clinic visit. {T}he prevalence of chronic {HBV} infection will be estimated in the general population and in key subgroups. {R}isk factors for {HBV} acquisition in children will be explored using case-control analysis. {HBV} burden will be assessed through comparisons of health and economic outcomes between households affected by the disease versus non-affected households. {L}ast, an economic evaluation will assess costs and health benefits of scaling-up {HBV} care. {E}thics and dissemination {T}his study was approved by the {S}enegalese {N}ational {E}thical {C}ommittee for {R}esearch in {H}ealth, and received authorisation from the {S}enegalese {M}inistry of {H}ealth and the {F}rench {C}ommission on {I}nformation {T}echnology and {L}iberties ({S}enegalese {P}rotocol {N}umber: {SEN}17/15). {T}he study results will be presented in peer-review journals, international conferences and at a workshop with national stakeholders in order to contribute to the design of programmes to address the {HBV} pandemic.},
  keywords = {{SENEGAL} ; {NIAKHAR}},
  booktitle = {},
  journal = {{BMJ} {O}pen},
  volume = {9},
  numero = {7},
  pages = {e030211 [11 ]},
  ISSN = {2044-6055},
  year = {2019},
  DOI = {10.1136/bmjopen-2019-030211},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077037},
}