@article{fdi:010077004,
  title = {{M}easuring malaria morbidity in an area of seasonal transmission : pyrogenic parasitemia thresholds based on a 20-year follow-up study},
  author = {{D}ollat, {M}. and {T}alla, {C}. and {S}okhna, {C}heikh and {S}arr, {F}. {D}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {R}ichard, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {A}symptomatic carriage of {P}. falciparum is frequent in areas endemic for malaria and individual diagnosis of clinical malaria attacks is still difficult. {W}e investigated the impact of changes in malaria endemicity on the diagnostic criteria for malaria attacks in an area of seasonal malaria transmission. {M}ethods {W}e analyzed the longitudinal data collected over 20 years from a daily survey of all inhabitants of {N}diop, a rural community in central {S}enegal, in a logistic regression model to investigate the relationship between the level of {P}lasmodium falciparum parasitemia and the risk of fever, with the aim of determining the best parasitemia thresholds for attributing to malaria a fever episode. {R}esults {A} total of 34,136 observations recorded from {J}uly 1993 to {D}ecember 2013 from 850 individuals aged from 1 day to 87 years were included. {P}. falciparum asymptomatic carriage declined from 36% to 1% between 1993 and 2013. {A} total of 9,819 fever episodes were associated with a positive blood film for {P}. falciparum. {U}sing age-dependent parasitemia thresholds for attributing to malaria a fever episode, we recorded 6,006 malaria attacks during the study period. {P}arasitemia thresholds seemed to be lower during the low-to-zero transmission season and tended to decrease with changes in control policies. {T}he number of clinical malaria attacks was overestimated for all age groups throughout the study when all fever episodes associated with {P}. falciparum parasitemia were defined as malaria attacks. {C}onclusion {P}yrogenic thresholds are particularly sensitive to changes in malaria epidemiology and are therefore an interesting tool to accurately assess the burden of malaria in the context of declining transmission.},
  keywords = {{SENEGAL} ; {NDIOP}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {14},
  numero = {6},
  pages = {art. e0217903 [18 ]},
  ISSN = {1932-6203},
  year = {2019},
  DOI = {10.1371/journal.pone.0217903},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077004},
}