%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Leman-Loubière, C.
%A Le Goff, G.
%A Debitus, Cécile
%A Ouazzani, J.
%T Sporochartines A-E, a new family of natural products from the marine fungus Hypoxylon monticulosum isolated from a Sphaerocladina sponge
%D 2017
%L fdi:010076701
%G ENG
%J Frontiers in Marine Science
%@ 2296-7745
%K TAHITI ; PACIFIQUE
%M ISI:000457690600396
%P art. 399
%R 10.3389/fmars.2017.00399
%U https://www.documentation.ird.fr/hor/fdi:010076701
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-08/010076701.pdf
%V 4
%W Horizon (IRD)
%X Four new sporochartines B-E were isolated from the marine fungus Hypoxylon monticulosurn CLL-205, isolated from a sponge belonging to the Sphaerocladina order and collected in Tahiti coast. Sporochartine A (1), the first representative of this family was previously isolated from the same fungus. The structures of sporochartines B-E were elucidated using 1D and 2D NMR, HRMS and IR data. Their configurations were established according to ROE correlations and comparison with the absolute configuration of sporochartine A (1) previously obtained from X-ray analysis. Sporochartines A-D (2-4) may be derived from endo Diels-Alderase type catalysis and sporochartine E (5) from an exo Diels-Alderase catalysis. The spatial conformation of sporochartines drastically influences the results of the cytotoxic bioassay against HCT-116, PC-3, and MCF-7 human cancer cell lines.
%$ 035