Leman-Loubière C., Le Goff G., Debitus Cécile, Ouazzani J. (2017). Sporochartines A-E, a new family of natural products from the marine fungus Hypoxylon monticulosum isolated from a Sphaerocladina sponge. Frontiers in Marine Science, 4, art. 399. ISSN 2296-7745.
Titre du document
Sporochartines A-E, a new family of natural products from the marine fungus Hypoxylon monticulosum isolated from a Sphaerocladina sponge
Leman-Loubière C., Le Goff G., Debitus Cécile, Ouazzani J.
Source
Frontiers in Marine Science, 2017,
4, art. 399 ISSN 2296-7745
Four new sporochartines B-E were isolated from the marine fungus Hypoxylon monticulosurn CLL-205, isolated from a sponge belonging to the Sphaerocladina order and collected in Tahiti coast. Sporochartine A (1), the first representative of this family was previously isolated from the same fungus. The structures of sporochartines B-E were elucidated using 1D and 2D NMR, HRMS and IR data. Their configurations were established according to ROE correlations and comparison with the absolute configuration of sporochartine A (1) previously obtained from X-ray analysis. Sporochartines A-D (2-4) may be derived from endo Diels-Alderase type catalysis and sporochartine E (5) from an exo Diels-Alderase catalysis. The spatial conformation of sporochartines drastically influences the results of the cytotoxic bioassay against HCT-116, PC-3, and MCF-7 human cancer cell lines.
