@article{fdi:010076614,
  title = {{S}eparating the local and malignant dimensions of cancer adaptation},
  author = {{R}oche, {B}enjamin and {M}artinez, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he repeatability observed across cancers arising in the same tissue can help understand the evolutionary process of tumour initiation. {W}e recently developed a framework to quantify the local malignant adaptation of genetic clones in tissue-specific environments, {I}n this {C}ommentary, we argue that such a 1-dimensional model can be improved by separating its 2 components to obtain a dual scale: local adaptation, dictating proliferation rates in the local environment, and malignant adaptation, influencing the likelihood that a clone becomes cancerous and invasive. {S}uch a change could strengthen our understanding of the population dynamics underlying cancer initiation and assess different evolutionary scenarios.},
  keywords = {{C}ancer ; genetics ; evolution ; somatic mutations ; bioinformatics},
  booktitle = {},
  journal = {{C}ancer {I}nformatics},
  volume = {18},
  numero = {},
  pages = {art. 1176935119872954 [3 p.]},
  year = {2019},
  DOI = {10.1177/1176935119872954},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076614},
}