@article{fdi:010076246,
  title = {{S}olid state fermentation pilot-scaled plug flow bioreactor, using partial least square regression to predict the residence time in a semicontinuous process},
  author = {{C}arbou{\'e}, {Q}. and {R}ebufa, {C}. and {D}upuy, {N}. and {R}oussos, {S}evastianos and {B}ombarda, {I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lug flow bioreactor ({PFB}) used in solid state fermentation gives the possibility to have semicontinuous culture. {H}owever, it is complicated to follow a single particle during its residence inside the bioreactor and to therefore study precisely the culture process all along the device. {I}n this study, semicontinuous production of fungal compounds was successfully obtained by cultivating {A}spergillus niger with a {PFB} prototype. {K}inetic productions of the same metabolites along the bioreactor were obtained at laboratory scale to predict the residence time of the particles inside the {PFB} from {P}artial {L}east {S}quare ({PLS}). {T}his original methodology allowed (1) the comparison between the production kinetics at the two production scales (pilot and laboratory) and (2) the observation of eventual changes following the scale-up of the process offering a good overall insight of the {PFB} performance.},
  keywords = {{P}lug flow bioreactor ; {S}olid state fermentation ; {P}artial least square regression ; {R}esidence time ; {A}spergillus niger},
  booktitle = {},
  journal = {{B}iochemical {E}ngineering {J}ournal},
  volume = {149},
  numero = {},
  pages = {art. 107248 [9 ]},
  ISSN = {1369-703{X}},
  year = {2019},
  DOI = {10.1016/j.bej.2019.107248},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076246},
}