@article{fdi:010075684,
  title = {{E}stimating the current burden of {C}hagas disease in {M}exico : a systematic review and meta-analysis of epidemiological surveys from 2006 to 2017},
  author = {{A}rnal, {A}. and {W}aleckx, {E}tienne and {R}ico-{C}havez, {O}. and {H}errera, {C}. and {D}umonteil, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}n {M}exico, estimates of {C}hagas disease prevalence and burden vary widely. {U}pdating surveillance data is therefore an important priority to ensure that {C}hagas disease does not remain a barrier to the development of {M}exico's most vulnerable populations. {M}ethodology/{P}rincipal findings {T}he aim of this systematic review and meta-analysis was to analyze the literature on epidemiological surveys to estimate {C}hagas disease prevalence and burden in {M}exico, during the period 2006 to 2017. {A} total of 2,764 articles were screened and 36 were retained for the final analysis. {E}pidemiological surveys have been performed in most of {M}exico, but with variable study scale and geographic coverage. {B}ased on studies reporting confirmed cases (i.e. using at least 2 serological tests), and taking into account the differences in sample sizes, the national estimated seroprevalence of {T}rypanosoma cruzi infection was 3.38% [95%{CI} 2.59-4.16], suggesting that there are 4.06 million cases in {M}exico. {S}tudies focused on pregnant women, which may transmit the parasite to their newborn during pregnancy, reported an estimated seroprevalence of 2.21% [95%{CI} 1.46-2.96], suggesting that there are 50,675 births from {T}. cruzi infected pregnant women per year, and 3,193 cases of congenitally infected newborns per year. {C}hildren under 18 years had an estimated seropositivity rate of 1.51% [95%{CI} 0.77-2.25], which indicate ongoing transmission. {C}ases of {T}. cruzi infection in blood donors have also been reported in most states, with a national estimated seroprevalence of 0.55% [95%{CI} 0.43-0.66]. {C}onclusions/{S}ignificance {O}ur analysis suggests a disease burden for {T}. cruzi infection higher than previously recognized, highlighting the urgency of establishing {C}hagas disease surveillance and control as a key national public health priority in {M}exico, to ensure that it does not remain a major barrier to the economic and social development of the country's most vulnerable populations.},
  keywords = {{MEXIQUE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {13},
  numero = {4},
  pages = {e0006859 [19p.]},
  ISSN = {1935-2735},
  year = {2019},
  DOI = {10.1371/journal.pntd.0006859},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075684},
}