@article{fdi:010075616,
  title = {{M}anagement of central nervous system infections, {V}ientiane, {L}aos, 2003-2011},
  author = {{D}ubot {P}{\'e}r{\`e}s, {A}udrey and {M}ayxay, {M}. and {P}hetsouvanh, {R}. and {L}ee, {S}. {J}. and {R}attanavong, {S}. and {V}ongsouvath, {M}. and {D}avong, {V}. and {C}hansamouth, {V}. and {P}hommasone, {K}. and {M}oore, {C}. and {D}ittrich, {S}. and {L}attana, {O}. and {S}irisouk, {J}. and {P}houmin, {P}. and {P}anyanivong, {P}. and {S}engduangphachanh, {A}. and {S}ibounheuang, {B}. and {C}hanthongthip, {A}. and {S}immalavong, {M}. and {S}engdatka, {D}. and {S}eubsanith, {A}. and {K}eoluangkot, {V}. and {P}himmasone, {P}. and {S}isout, {K}. and {D}etleuxay, {K}. and {L}uangxay, {K}. and {P}houangsouvanh, {I}. and {C}raig, {S}. {B}. and {T}ulsiani, {S}. {M}. and {B}urns, {M}. {A}. and {D}ance, {D}. {A}. {B}. and {B}lacksell, {S}. {D}. and {D}e {L}amballerie, {X}. and {N}ewton, {P}. {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}uring 2003-2011, we recruited 1,065 patients of all ages admitted to {M}ahosot {H}ospital ({V}ientiane, {L}aos) with suspected central nervous system ({CNS}) infection. {E}tiologies were laboratory confirmed for 42.3% of patients, who mostly had infections with emerging pathogens: viruses in 16.2% (mainly {J}apanese encephalitis virus [8.8%]); bacteria in 16.4% (including {O}rientia tsutsugamushi [2.9%], {L}eptospira spp. [2.3%], and {R}ickettsia spp. [2.3%]); and {C}ryptococcus spp. fungi in 6.6%. {W}e observed no significant differences in distribution of clinical encephalitis and meningitis by bacterial or viral etiology. {H}owever, patients with bacterial {CNS} infection were more likely to have a history of diabetes than others. {D}eath (26.3%) was associated with low {G}lasgow {C}oma {S}cale score, and the mortality rate was higher for patients with bacterial than viral infections. {N}o clinical or laboratory variables could guide antibiotic selection. {W}e conclude that high-dependency units and first-line treatment with ceftriaxone and doxycycline for suspected {CNS} infections could improve patient survival in {L}aos.},
  keywords = {{LAOS} ; {VIENTIANE}},
  booktitle = {},
  journal = {{E}merging {I}nfectious {D}iseases},
  volume = {25},
  numero = {5},
  pages = {898--910},
  ISSN = {1080-6040},
  year = {2019},
  DOI = {10.3201/eid2505.180914},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075616},
}