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Vinken L., Fransen K., Cuypers L., Alexiev I., Balotta C., Debaisieux L., Seguin-Devaux C., Ribas S. G., Gomes P., Incardona F., Kaiser R., Ruelle J., Sayan M., Paraschiv S., Paredes R., Peeters Martine, Sonnerborg A., Vancutsem E., Vandamme A. M., Van den Wijngaert S., Van Ranst M., Verhofstede C., Stadler T., Lemey P., Van Laethem K. (2019). Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium. Frontiers in Microbiology, 10, art. 613 [11 p.]. ISSN 1664-302X

Fichier PDF disponiblehttp://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-04/010075505.pdf[ PDF Link ]

Lien direct chez l'éditeur doi:10.3389/fmicb.2019.00613

Titre
Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium
Année de publication2019
Type de documentArticle référencé dans le Web of Science WOS:000462516100001
AuteursVinken L., Fransen K., Cuypers L., Alexiev I., Balotta C., Debaisieux L., Seguin-Devaux C., Ribas S. G., Gomes P., Incardona F., Kaiser R., Ruelle J., Sayan M., Paraschiv S., Paredes R., Peeters Martine, Sonnerborg A., Vancutsem E., Vandamme A. M., Van den Wijngaert S., Van Ranst M., Verhofstede C., Stadler T., Lemey P., Van Laethem K.
SourceFrontiers in Microbiology, 2019, 10, p. art. 613 [11 p.]. p. art. 613 [11 p.] ISSN 1664-302X
RésuméHuman immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, the Belgian AIDS Reference Laboratories collected HIV-1 pol sequences from all subsubtype F1-infected patients for whom genotypic drug resistance testing was requested as part of routine clinical follow-up. This data was complemented with HIV-1 pol sequences from countries with a high burden of F1 infections or a potential role in the global origin of sub-subtype F1. The molecular epidemiology of the Belgian subtype F1 epidemic was investigated using Bayesian phylogenetic inference and transmission dynamics were characterized based on birth-death models. F1 sequences were retained from 297 patients diagnosed and linked to care in Belgium between 1988 and 2015. Phylogenetic inference indicated that among the 297 Belgian F1 sequences, 191 belonged to a monophyletic group that mainly contained sequences from people likely infected in Belgium (OR 26.67, 95% CI 9.59-74.15), diagnosed in Flanders (OR 7.28, 95% CI 4.23-12.53), diagnosed at a recent stage of infection (OR 7.19, 95% CI 2.88-17.95) or declared to be MSM (OR 34.8, 95% CI 16.0-75.6). Together with a Spanish clade, this Belgian clade was embedded in the genetic diversity of Brazilian subtype F1 strains and most probably emerged after one or only a few migration events from Brazil to the European continent before 2002. The origin of the Belgian outbreak was dated back to 2002 (95% higher posterior density 2000-2004) and birth-death models suggested that its extensive growth had been controlled (R-e < 1) by 2012, coinciding with a time period where delay in antiretroviral treatment initiation substantially declined. In conclusion, phylogenetic reconstruction of the Belgian HIV-1 sub-subtype F1 epidemic illustrates the introduction and substantial dissemination of viral strains in a geographically restricted risk group that was most likely controlled by effective treatment as prevention.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
Descr. géo.BELGIQUE
LocalisationFonds IRD [F B010075505]
Identifiant IRDfdi:010075505
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010075505

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