@article{fdi:010075502,
  title = {{I}mpact of 19 years of mass drug administration with ivermectin on epilepsy burden in a hyperendemic onchocerciasis area in {C}ameroon},
  author = {{B}oulle, {C}. and {N}jamnshi, {A}. {K}. and {D}ema, {F}. and {M}engnjo, {M}. {K}. and {F}odjo, {J}. {N}. {S}. and {B}issek, {A}czk and {S}uykerbuyk, {P}. and {L}enou-{N}anga, {C}. {G}. and {N}ana-{D}jeunga, {H}. {C}. and {K}amgno, {J}. and {C}hesnais, {C}edric and {B}oussinesq, {M}ichel and {C}olebunders, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground{S}urveys conducted in 1991-1992 in the {M}bam {V}alley ({C}ameroon) revealed that onchocerciasis was highly endemic, with community microfilarial loads ({CMFL})>100 microfilariae/snip in some villages. {A}lso in 1991-1992, a survey of suspected cases of epilepsy ({SCE}) found 746 {SCE} using a questionnaire administered to individuals identified by key informants, with prevalences reaching 13.6% in some communities. {F}rom 1998, annual community-directed treatment with ivermectin ({CDTI}) was implemented to control onchocerciasis. {I}n 2017, a door-to-door household survey was conducted in three of the villages visited in 1991-1992, using a standardized 5-item epilepsy screening questionnaire.{R}esults{I}n 2017, a total of 2286 individuals living in 324 households were screened (582 in {B}ayomen, 553 in {N}gongol and 1151 in {N}yamongo) and 112 {SCE} were identified (4.9%). {N}eurologists examined 92 of these {SCE} and confirmed the diagnosis of epilepsy for 81 of them (3.5%). {B}etween the surveys in 1991-1992 and 2017, the prevalence of {SCE} decreased from 13.6% to 2.5% in {B}ayomen ({P}=0.001), from 8.7% to 6.6% in {N}gongol ({P}=0.205) and from 6.4% to 5.4% in {N}yamongo ({P}=0.282). {T}he median age of {SCE} shifted from 20 ({IQR}: 12-23) to 29years ({IQR}: 18-33; {P}=0.018) in {B}ayomen, from 16 ({IQR}: 12-21) to 26years ({IQR}: 21-39; {P}<0.001) in {N}gongol and from 16 ({IQR}: 13-19) to 24years ({IQR}: 19-32; {P}<0.001) in {N}yamongo. {T}he proportions of {SCE} aged <10, 10-19, 20-29 and 30years shifted from 9.5, 58.3, 25.0 and 7.1% in 1991-1992 to 2.7, 20.5, 39.3 and 37.5% in 2017, respectively.{C}onclusions{SCE} prevalence decreased overall between 1991-1992 and 2017. {T}he age shift observed is probably due to a decrease in the number of new cases of epilepsy resulting from the dramatic reduction of {O}nchocerca volvulus transmission after 19years of {CDTI}.},
  keywords = {{C}ameroon ; {E}pilepsy ; {O}nchocerciasis ; {C}ommunity study ; {CAMEROUN}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {12},
  numero = {},
  pages = {art. 114 [13 ]},
  ISSN = {1756-3305},
  year = {2019},
  DOI = {10.1186/s13071-019-3345-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075502},
}