%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Trung, N. V.
%A Hoi, L.
%A Dien, V. M.
%A Huong, D. T.
%A Hoa, T. M.
%A Lien, V. N.
%A Luan, V.
%A Lewycka, S. O.
%A Choisy, Marc
%A Bryant, J. E.
%A Nadjm, B.
%A Van Doorn, H. R.
%A Richards, A. L.
%A Van Kinh, N.
%T Clinical manifestations and molecular diagnosis of scrub typhus and murine typhus Vietnam, 2015-2017
%D 2019
%L fdi:010075483
%G ENG
%J Emerging Infectious Diseases
%@ 1080-6040
%K VIET NAM
%M ISI:000461604500002
%N 4
%P 633-641
%R 10.3201/eid2504.180691
%U https://www.documentation.ird.fr/hor/fdi:010075483
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers19-04/010075483.pdf
%V 25
%W Horizon (IRD)
%X Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsia' diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015-March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam.
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