@article{fdi:010075325,
  title = {{I}ndirect neonatal hyperbilirubinemia in hospitalized neonates on the {T}hai-{M}yanmar border : a review of neonatal medical records from 2009 to 2014},
  author = {{T}hielemans, {L}. and {T}rip-{H}oving, {M}. and {L}andier, {J}ordi and {T}urner, {C}. and {P}rins, {T}.{J}. and {W}ouda, {E}.{M}.{N}. and {H}anboonkunupakarn, {B}. and {P}o, {C}. and {B}eau, {C}. and {M}u, {M}. and {H}annay, {T}. and {N}osten, {F}. and {V}an {O}vermeire, {B}. and {M}c{G}eady, {R}. and {C}arrara, {V}.{I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}ndirect neonatal hyperbilirubinemia ({INH}) is a common neonatal disorder worldwide which can remain benign if prompt management is available. {H}owever there is a higher morbidity and mortality risk in settings with limited access to diagnosis and care. {T}he manuscript describes the characteristics of neonates with {INH}, the burden of severe {INH} and identifies factors associated with severity in a resource-constrained setting. {M}ethods: {W}e conducted a retrospective evaluation of anonymized records of neonates hospitalized on the {T}hai-{M}yanmar border. {INH} was defined according to the {N}ational {I}nstitute for {H}ealth and {C}are {E}xcellence guidelines as 'moderate' if at least one serum bilirubin ({SBR}) value exceeded the phototherapy threshold and as 'severe' if above the exchange transfusion threshold. {R}esults: {O}ut of 2980 records reviewed, 1580 (53%) had {INH} within the first 14 days of life. {INH} was moderate in 87% (1368/1580) and severe in 13% (212/1580). {F}rom 2009 to 2011, the proportion of severe {INH} decreased from 37 to 15% and the mortality dropped from 10% (8/82) to 2% (7/449) coinciding with the implementation of standardized guidelines and light-emitting diode ({LED}) phototherapy. {S}evere {INH} was associated with: prematurity (< 32 weeks, {A}djusted {O}dds {R}atio ({AOR}) 3.3; 95% {CI} 1.6-6.6 and 32 to 37 weeks, {AOR} 2.2; 95% {CI} 1.6-3.1), {G}lucose-6-phosphate dehydrogenase deficiency ({G}6{PD}) ({AOR} 2.3; 95% {CI} 1.6-3.3), potential {ABO} incompatibility ({AOR} 1.5; 95% {CI} 1.0-2.2) and late presentation ({AOR} 1.8; 95% {CI} 1.3-2.6). {T}he risk of developing severe {INH} and {INH}-related mortality significantly increased with each additional risk factor. {C}onclusion: {INH} is an important cause of neonatal hospitalization on the {T}hai-{M}yanmar border. {R}isk factors for severity were similar to previous reports from {A}sia. {I}mplementing standardized guidelines and appropriate treatment was successful in reducing mortality and severity. {A}ccessing to basic neonatal care including {SBR} testing, {LED} phototherapy and {G}6{PD} screening can contribute to improve neonatal outcomes.},
  keywords = {{MYANMAR}},
  booktitle = {},
  journal = {{BMC} {P}ediatrics},
  volume = {18},
  numero = {},
  pages = {art. no 190 [11 ]},
  ISSN = {1471-2431},
  year = {2018},
  DOI = {10.1186/s12887-018-1165-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075325},
}