@article{fdi:010075305,
  title = {{L}ow {Z}ika virus seroprevalence in {V}ientiane, {L}aos, 2003-2015},
  author = {{P}astorino, {B}. and {S}engvilaipaseuth, {O}. and {C}hanthongthip, {A}. and {V}ongsouvath, {M}. and {S}ouksakhone, {C}. and {M}ayxay, {M}. and {T}hirion, {L}aurence and {N}ewton, {P}. {N}. and {L}amballerie, {X}. de and {D}ubot {P}{\'e}r{\`e}s, {A}udrey},
  editor = {},
  language = {{ENG}},
  abstract = {{Z}ika virus ({ZIKV}) has been presumed to be endemic in {S}outheast {A}sia ({SEA}), with a low rate of human infections. {A}lthough the first {ZIKV} evidence was obtained in the 1950s through serosurveys, the first laboratory-confirmed case was only detected in 2010 in {C}ambodia. {T}he epidemiology of {ZIKV} in {SEA} remains uncertain because of the scarcity of available data. {F}rom 2016, subsequent to the large outbreaks in the {P}acific and {L}atin {A}merica, several {A}sian countries started reporting increasing numbers of confirmed {ZIKV} patients, but no global epidemiological assessment is available to date. {H}ere, with the aim of providing information on {ZIKV} circulation and population immunity, we conducted a seroprevalence study among blood donors in {V}ientiane, {L}aos. {S}era from 359 asymptomatic consenting adult donors in 2003-2004 and 687 in 2015 were screened for anti-{ZIKV} {I}g{G} using {NS}1 {ELISA} assay ({E}uroimmun, {L}uebeck, {G}ermany). {P}ositive and equivocal samples were confirmed for anti-{ZIKV}-neutralizing antibodies by virus neutralization tests. {O}ur findings suggest that {ZIKV} has been circulating in {V}ientiane over at least the last decade. {Z}ika virus seroprevalence observed in the studied blood donors was low, 4.5% in 2003-2004 with an increase in 2015 to 9.9% ({P} = 0.002), possibly reflecting the increase of {ZIKV} incident cases reported over this period. {W}e did not observe any significant difference in seroprevalence according to gender. {W}ith a low herd immunity in the {V}ientiane population, {ZIKV} represents a risk for future large-scale outbreaks. {I}mplementation of a nationwide {ZIKV} surveillance network and epidemiological studies throughout the country is needed.},
  keywords = {{LAOS} ; {VIENTIANE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {100},
  numero = {3},
  pages = {639--642},
  ISSN = {0002-9637},
  year = {2019},
  DOI = {10.4269/ajtmh.18-0439},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075305},
}